Cargando…
Circulating CD40 and sCD40L Predict Changes in Renal Function in Subjects with Chronic Kidney Disease
Soluble CD40 ligand (sCD40L) has been implicated in the development of renal injury. The CD40 receptor exists in a soluble form, sCD40R, and has been shown to function as a competitive antagonist against CD40 activation. We analyzed whether plasma levels of sCD40L and sCD40R predict changes in renal...
Autores principales: | , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554219/ https://www.ncbi.nlm.nih.gov/pubmed/28801616 http://dx.doi.org/10.1038/s41598-017-08426-8 |
_version_ | 1783256751762571264 |
---|---|
author | Xie, Jeffrey X. Alderson, Helen Ritchie, James Kalra, Philip A. Xie, Yanmei Ren, Kaili Nguyen, Hanh Chen, Tian Brewster, Pamela Gupta, Rajesh Dworkin, Lance D. Malhotra, Deepak Cooper, Christopher J. Tian, Jiang Haller, Steven T. |
author_facet | Xie, Jeffrey X. Alderson, Helen Ritchie, James Kalra, Philip A. Xie, Yanmei Ren, Kaili Nguyen, Hanh Chen, Tian Brewster, Pamela Gupta, Rajesh Dworkin, Lance D. Malhotra, Deepak Cooper, Christopher J. Tian, Jiang Haller, Steven T. |
author_sort | Xie, Jeffrey X. |
collection | PubMed |
description | Soluble CD40 ligand (sCD40L) has been implicated in the development of renal injury. The CD40 receptor exists in a soluble form, sCD40R, and has been shown to function as a competitive antagonist against CD40 activation. We analyzed whether plasma levels of sCD40L and sCD40R predict changes in renal function in an all-cause chronic kidney disease (CKD) cohort. Stratification of subjects based on sCD40L and sCD40R individually, as well as in combination, demonstrated that sCD40L was directly associated with declines in estimated glomerular filtration rate (eGFR). sCD40R was negatively associated with declines in eGFR. Baseline characteristics following stratification, including systolic blood pressure, history of diabetes mellitus or peripheral vascular disease, primary renal disease classification, and angiotensin converting enzyme inhibitor or angiotensin receptor blocker usage were not significantly different. High sCD40L and low sCD40R were both found to be independent predictors of a decline in eGFR at 1-year follow-up (−7.57%, p = 0.014; −6.39%, p = 0.044). Our data suggest that circulating levels of sCD40L and sCD40R are associated with changes in renal function in patients with CKD. The CD40 decoy receptor, sCD40R, may serve as a potential therapeutic target to attenuate renal function decline. |
format | Online Article Text |
id | pubmed-5554219 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-55542192017-08-15 Circulating CD40 and sCD40L Predict Changes in Renal Function in Subjects with Chronic Kidney Disease Xie, Jeffrey X. Alderson, Helen Ritchie, James Kalra, Philip A. Xie, Yanmei Ren, Kaili Nguyen, Hanh Chen, Tian Brewster, Pamela Gupta, Rajesh Dworkin, Lance D. Malhotra, Deepak Cooper, Christopher J. Tian, Jiang Haller, Steven T. Sci Rep Article Soluble CD40 ligand (sCD40L) has been implicated in the development of renal injury. The CD40 receptor exists in a soluble form, sCD40R, and has been shown to function as a competitive antagonist against CD40 activation. We analyzed whether plasma levels of sCD40L and sCD40R predict changes in renal function in an all-cause chronic kidney disease (CKD) cohort. Stratification of subjects based on sCD40L and sCD40R individually, as well as in combination, demonstrated that sCD40L was directly associated with declines in estimated glomerular filtration rate (eGFR). sCD40R was negatively associated with declines in eGFR. Baseline characteristics following stratification, including systolic blood pressure, history of diabetes mellitus or peripheral vascular disease, primary renal disease classification, and angiotensin converting enzyme inhibitor or angiotensin receptor blocker usage were not significantly different. High sCD40L and low sCD40R were both found to be independent predictors of a decline in eGFR at 1-year follow-up (−7.57%, p = 0.014; −6.39%, p = 0.044). Our data suggest that circulating levels of sCD40L and sCD40R are associated with changes in renal function in patients with CKD. The CD40 decoy receptor, sCD40R, may serve as a potential therapeutic target to attenuate renal function decline. Nature Publishing Group UK 2017-08-11 /pmc/articles/PMC5554219/ /pubmed/28801616 http://dx.doi.org/10.1038/s41598-017-08426-8 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Xie, Jeffrey X. Alderson, Helen Ritchie, James Kalra, Philip A. Xie, Yanmei Ren, Kaili Nguyen, Hanh Chen, Tian Brewster, Pamela Gupta, Rajesh Dworkin, Lance D. Malhotra, Deepak Cooper, Christopher J. Tian, Jiang Haller, Steven T. Circulating CD40 and sCD40L Predict Changes in Renal Function in Subjects with Chronic Kidney Disease |
title | Circulating CD40 and sCD40L Predict Changes in Renal Function in Subjects with Chronic Kidney Disease |
title_full | Circulating CD40 and sCD40L Predict Changes in Renal Function in Subjects with Chronic Kidney Disease |
title_fullStr | Circulating CD40 and sCD40L Predict Changes in Renal Function in Subjects with Chronic Kidney Disease |
title_full_unstemmed | Circulating CD40 and sCD40L Predict Changes in Renal Function in Subjects with Chronic Kidney Disease |
title_short | Circulating CD40 and sCD40L Predict Changes in Renal Function in Subjects with Chronic Kidney Disease |
title_sort | circulating cd40 and scd40l predict changes in renal function in subjects with chronic kidney disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554219/ https://www.ncbi.nlm.nih.gov/pubmed/28801616 http://dx.doi.org/10.1038/s41598-017-08426-8 |
work_keys_str_mv | AT xiejeffreyx circulatingcd40andscd40lpredictchangesinrenalfunctioninsubjectswithchronickidneydisease AT aldersonhelen circulatingcd40andscd40lpredictchangesinrenalfunctioninsubjectswithchronickidneydisease AT ritchiejames circulatingcd40andscd40lpredictchangesinrenalfunctioninsubjectswithchronickidneydisease AT kalraphilipa circulatingcd40andscd40lpredictchangesinrenalfunctioninsubjectswithchronickidneydisease AT xieyanmei circulatingcd40andscd40lpredictchangesinrenalfunctioninsubjectswithchronickidneydisease AT renkaili circulatingcd40andscd40lpredictchangesinrenalfunctioninsubjectswithchronickidneydisease AT nguyenhanh circulatingcd40andscd40lpredictchangesinrenalfunctioninsubjectswithchronickidneydisease AT chentian circulatingcd40andscd40lpredictchangesinrenalfunctioninsubjectswithchronickidneydisease AT brewsterpamela circulatingcd40andscd40lpredictchangesinrenalfunctioninsubjectswithchronickidneydisease AT guptarajesh circulatingcd40andscd40lpredictchangesinrenalfunctioninsubjectswithchronickidneydisease AT dworkinlanced circulatingcd40andscd40lpredictchangesinrenalfunctioninsubjectswithchronickidneydisease AT malhotradeepak circulatingcd40andscd40lpredictchangesinrenalfunctioninsubjectswithchronickidneydisease AT cooperchristopherj circulatingcd40andscd40lpredictchangesinrenalfunctioninsubjectswithchronickidneydisease AT tianjiang circulatingcd40andscd40lpredictchangesinrenalfunctioninsubjectswithchronickidneydisease AT hallerstevent circulatingcd40andscd40lpredictchangesinrenalfunctioninsubjectswithchronickidneydisease |