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Circulating CD40 and sCD40L Predict Changes in Renal Function in Subjects with Chronic Kidney Disease

Soluble CD40 ligand (sCD40L) has been implicated in the development of renal injury. The CD40 receptor exists in a soluble form, sCD40R, and has been shown to function as a competitive antagonist against CD40 activation. We analyzed whether plasma levels of sCD40L and sCD40R predict changes in renal...

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Autores principales: Xie, Jeffrey X., Alderson, Helen, Ritchie, James, Kalra, Philip A., Xie, Yanmei, Ren, Kaili, Nguyen, Hanh, Chen, Tian, Brewster, Pamela, Gupta, Rajesh, Dworkin, Lance D., Malhotra, Deepak, Cooper, Christopher J., Tian, Jiang, Haller, Steven T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554219/
https://www.ncbi.nlm.nih.gov/pubmed/28801616
http://dx.doi.org/10.1038/s41598-017-08426-8
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author Xie, Jeffrey X.
Alderson, Helen
Ritchie, James
Kalra, Philip A.
Xie, Yanmei
Ren, Kaili
Nguyen, Hanh
Chen, Tian
Brewster, Pamela
Gupta, Rajesh
Dworkin, Lance D.
Malhotra, Deepak
Cooper, Christopher J.
Tian, Jiang
Haller, Steven T.
author_facet Xie, Jeffrey X.
Alderson, Helen
Ritchie, James
Kalra, Philip A.
Xie, Yanmei
Ren, Kaili
Nguyen, Hanh
Chen, Tian
Brewster, Pamela
Gupta, Rajesh
Dworkin, Lance D.
Malhotra, Deepak
Cooper, Christopher J.
Tian, Jiang
Haller, Steven T.
author_sort Xie, Jeffrey X.
collection PubMed
description Soluble CD40 ligand (sCD40L) has been implicated in the development of renal injury. The CD40 receptor exists in a soluble form, sCD40R, and has been shown to function as a competitive antagonist against CD40 activation. We analyzed whether plasma levels of sCD40L and sCD40R predict changes in renal function in an all-cause chronic kidney disease (CKD) cohort. Stratification of subjects based on sCD40L and sCD40R individually, as well as in combination, demonstrated that sCD40L was directly associated with declines in estimated glomerular filtration rate (eGFR). sCD40R was negatively associated with declines in eGFR. Baseline characteristics following stratification, including systolic blood pressure, history of diabetes mellitus or peripheral vascular disease, primary renal disease classification, and angiotensin converting enzyme inhibitor or angiotensin receptor blocker usage were not significantly different. High sCD40L and low sCD40R were both found to be independent predictors of a decline in eGFR at 1-year follow-up (−7.57%, p = 0.014; −6.39%, p = 0.044). Our data suggest that circulating levels of sCD40L and sCD40R are associated with changes in renal function in patients with CKD. The CD40 decoy receptor, sCD40R, may serve as a potential therapeutic target to attenuate renal function decline.
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spelling pubmed-55542192017-08-15 Circulating CD40 and sCD40L Predict Changes in Renal Function in Subjects with Chronic Kidney Disease Xie, Jeffrey X. Alderson, Helen Ritchie, James Kalra, Philip A. Xie, Yanmei Ren, Kaili Nguyen, Hanh Chen, Tian Brewster, Pamela Gupta, Rajesh Dworkin, Lance D. Malhotra, Deepak Cooper, Christopher J. Tian, Jiang Haller, Steven T. Sci Rep Article Soluble CD40 ligand (sCD40L) has been implicated in the development of renal injury. The CD40 receptor exists in a soluble form, sCD40R, and has been shown to function as a competitive antagonist against CD40 activation. We analyzed whether plasma levels of sCD40L and sCD40R predict changes in renal function in an all-cause chronic kidney disease (CKD) cohort. Stratification of subjects based on sCD40L and sCD40R individually, as well as in combination, demonstrated that sCD40L was directly associated with declines in estimated glomerular filtration rate (eGFR). sCD40R was negatively associated with declines in eGFR. Baseline characteristics following stratification, including systolic blood pressure, history of diabetes mellitus or peripheral vascular disease, primary renal disease classification, and angiotensin converting enzyme inhibitor or angiotensin receptor blocker usage were not significantly different. High sCD40L and low sCD40R were both found to be independent predictors of a decline in eGFR at 1-year follow-up (−7.57%, p = 0.014; −6.39%, p = 0.044). Our data suggest that circulating levels of sCD40L and sCD40R are associated with changes in renal function in patients with CKD. The CD40 decoy receptor, sCD40R, may serve as a potential therapeutic target to attenuate renal function decline. Nature Publishing Group UK 2017-08-11 /pmc/articles/PMC5554219/ /pubmed/28801616 http://dx.doi.org/10.1038/s41598-017-08426-8 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Xie, Jeffrey X.
Alderson, Helen
Ritchie, James
Kalra, Philip A.
Xie, Yanmei
Ren, Kaili
Nguyen, Hanh
Chen, Tian
Brewster, Pamela
Gupta, Rajesh
Dworkin, Lance D.
Malhotra, Deepak
Cooper, Christopher J.
Tian, Jiang
Haller, Steven T.
Circulating CD40 and sCD40L Predict Changes in Renal Function in Subjects with Chronic Kidney Disease
title Circulating CD40 and sCD40L Predict Changes in Renal Function in Subjects with Chronic Kidney Disease
title_full Circulating CD40 and sCD40L Predict Changes in Renal Function in Subjects with Chronic Kidney Disease
title_fullStr Circulating CD40 and sCD40L Predict Changes in Renal Function in Subjects with Chronic Kidney Disease
title_full_unstemmed Circulating CD40 and sCD40L Predict Changes in Renal Function in Subjects with Chronic Kidney Disease
title_short Circulating CD40 and sCD40L Predict Changes in Renal Function in Subjects with Chronic Kidney Disease
title_sort circulating cd40 and scd40l predict changes in renal function in subjects with chronic kidney disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554219/
https://www.ncbi.nlm.nih.gov/pubmed/28801616
http://dx.doi.org/10.1038/s41598-017-08426-8
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