Pathophysiology and Clinical Utility of Non-coding RNAs in Epilepsy

Epilepsy is a common neurologic disorder. The underlying pathological processes include synaptic strength, inflammation, ion channels, and apoptosis. Acting as epigenetic factors, non-coding RNAs (ncRNAs) participate in the regulation of pathophysiologic processes of epilepsy and are dysregulated du...

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Detalles Bibliográficos
Autores principales: Shao, Yiye, Chen, Yinghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554344/
https://www.ncbi.nlm.nih.gov/pubmed/28848386
http://dx.doi.org/10.3389/fnmol.2017.00249
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author Shao, Yiye
Chen, Yinghui
author_facet Shao, Yiye
Chen, Yinghui
author_sort Shao, Yiye
collection PubMed
description Epilepsy is a common neurologic disorder. The underlying pathological processes include synaptic strength, inflammation, ion channels, and apoptosis. Acting as epigenetic factors, non-coding RNAs (ncRNAs) participate in the regulation of pathophysiologic processes of epilepsy and are dysregulated during epileptogenesis. Aberrant expression of ncRNAs are observed in epilepsy patients and animal models of epilepsy. Furthermore, ncRNAs might also be used as biomarkers for diagnosis and the prognosis of treatment response in epilepsy. In this review, we will summarize the role of ncRNAs in the pathophysiology of epilepsy and the putative utilization of ncRNAs as diagnostic biomarkers and therapeutic targets.
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spelling pubmed-55543442017-08-28 Pathophysiology and Clinical Utility of Non-coding RNAs in Epilepsy Shao, Yiye Chen, Yinghui Front Mol Neurosci Neuroscience Epilepsy is a common neurologic disorder. The underlying pathological processes include synaptic strength, inflammation, ion channels, and apoptosis. Acting as epigenetic factors, non-coding RNAs (ncRNAs) participate in the regulation of pathophysiologic processes of epilepsy and are dysregulated during epileptogenesis. Aberrant expression of ncRNAs are observed in epilepsy patients and animal models of epilepsy. Furthermore, ncRNAs might also be used as biomarkers for diagnosis and the prognosis of treatment response in epilepsy. In this review, we will summarize the role of ncRNAs in the pathophysiology of epilepsy and the putative utilization of ncRNAs as diagnostic biomarkers and therapeutic targets. Frontiers Media S.A. 2017-08-10 /pmc/articles/PMC5554344/ /pubmed/28848386 http://dx.doi.org/10.3389/fnmol.2017.00249 Text en Copyright © 2017 Shao and Chen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Shao, Yiye
Chen, Yinghui
Pathophysiology and Clinical Utility of Non-coding RNAs in Epilepsy
title Pathophysiology and Clinical Utility of Non-coding RNAs in Epilepsy
title_full Pathophysiology and Clinical Utility of Non-coding RNAs in Epilepsy
title_fullStr Pathophysiology and Clinical Utility of Non-coding RNAs in Epilepsy
title_full_unstemmed Pathophysiology and Clinical Utility of Non-coding RNAs in Epilepsy
title_short Pathophysiology and Clinical Utility of Non-coding RNAs in Epilepsy
title_sort pathophysiology and clinical utility of non-coding rnas in epilepsy
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554344/
https://www.ncbi.nlm.nih.gov/pubmed/28848386
http://dx.doi.org/10.3389/fnmol.2017.00249
work_keys_str_mv AT shaoyiye pathophysiologyandclinicalutilityofnoncodingrnasinepilepsy
AT chenyinghui pathophysiologyandclinicalutilityofnoncodingrnasinepilepsy

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