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AF-6 Protects Against Dopaminergic Dysfunction and Mitochondrial Abnormalities in Drosophila Models of Parkinson’s Disease

Afadin 6 (AF-6) is an F-actin binding multidomain-containing scaffolding protein that is known for its function in cell-cell adhesion. Interestingly, besides this well documented role, we recently found that AF-6 is a Parkin-interacting protein that augments Parkin/PINK1-mediated mitophagy. Notably,...

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Detalles Bibliográficos
Autores principales:	Basil, Adeline H., Sim, Joan P. L., Lim, Grace G. Y., Lin, Shuping, Chan, Hui Ying, Engelender, Simone, Lim, Kah-Leong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554356/ https://www.ncbi.nlm.nih.gov/pubmed/28848400 http://dx.doi.org/10.3389/fncel.2017.00241

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