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Incomplete Resolution of Deep Vein Thromboses during Rivaroxaban Therapy

We present the case of a patient with a deep vein thrombosis (DVT) who failed rivaroxaban therapy. Our patient initially presented with left lower extremity edema, erythema, and pain. He was subsequently started on rivaroxaban therapy for a combined treatment period of 12 months, during and after wh...

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Autores principales: Yaghoubian, Jonathan M., Adashek, Jacob, Yaghoubian-Yazi, Bahareh, Nagar, Menachem, Toomari, Nojan, Pietras, Richard J., Ben-Zur, Uri M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554577/
https://www.ncbi.nlm.nih.gov/pubmed/28828188
http://dx.doi.org/10.1155/2017/3628127
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author Yaghoubian, Jonathan M.
Adashek, Jacob
Yaghoubian-Yazi, Bahareh
Nagar, Menachem
Toomari, Nojan
Pietras, Richard J.
Ben-Zur, Uri M.
author_facet Yaghoubian, Jonathan M.
Adashek, Jacob
Yaghoubian-Yazi, Bahareh
Nagar, Menachem
Toomari, Nojan
Pietras, Richard J.
Ben-Zur, Uri M.
author_sort Yaghoubian, Jonathan M.
collection PubMed
description We present the case of a patient with a deep vein thrombosis (DVT) who failed rivaroxaban therapy. Our patient initially presented with left lower extremity edema, erythema, and pain. He was subsequently started on rivaroxaban therapy for a combined treatment period of 12 months, during and after which he persisted to have evidence of a DVT. The patient's prescribed drug regimen was changed from rivaroxaban to warfarin, which demonstrated a rapid resolution of the DVTs as determined by ultrasound assessment of our patient's lower extremity veins. Rivaroxaban, a factor Xa inhibitor, is a well-known oral anticoagulant that is used for a variety of indications and has become a mainstay in the treatment of deep vein thrombosis. With the introduction and emergence of this medication in the clinic, postmarketing reports of efficacy or lack thereof are important to review. In conclusion, we anticipate that it is likely that there are other patients with DVTs who may not respond to rivaroxaban and for whom alternative anticoagulation therapies should be explored.
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spelling pubmed-55545772017-08-21 Incomplete Resolution of Deep Vein Thromboses during Rivaroxaban Therapy Yaghoubian, Jonathan M. Adashek, Jacob Yaghoubian-Yazi, Bahareh Nagar, Menachem Toomari, Nojan Pietras, Richard J. Ben-Zur, Uri M. Case Rep Cardiol Case Report We present the case of a patient with a deep vein thrombosis (DVT) who failed rivaroxaban therapy. Our patient initially presented with left lower extremity edema, erythema, and pain. He was subsequently started on rivaroxaban therapy for a combined treatment period of 12 months, during and after which he persisted to have evidence of a DVT. The patient's prescribed drug regimen was changed from rivaroxaban to warfarin, which demonstrated a rapid resolution of the DVTs as determined by ultrasound assessment of our patient's lower extremity veins. Rivaroxaban, a factor Xa inhibitor, is a well-known oral anticoagulant that is used for a variety of indications and has become a mainstay in the treatment of deep vein thrombosis. With the introduction and emergence of this medication in the clinic, postmarketing reports of efficacy or lack thereof are important to review. In conclusion, we anticipate that it is likely that there are other patients with DVTs who may not respond to rivaroxaban and for whom alternative anticoagulation therapies should be explored. Hindawi 2017 2017-07-30 /pmc/articles/PMC5554577/ /pubmed/28828188 http://dx.doi.org/10.1155/2017/3628127 Text en Copyright © 2017 Jonathan M. Yaghoubian et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Yaghoubian, Jonathan M.
Adashek, Jacob
Yaghoubian-Yazi, Bahareh
Nagar, Menachem
Toomari, Nojan
Pietras, Richard J.
Ben-Zur, Uri M.
Incomplete Resolution of Deep Vein Thromboses during Rivaroxaban Therapy
title Incomplete Resolution of Deep Vein Thromboses during Rivaroxaban Therapy
title_full Incomplete Resolution of Deep Vein Thromboses during Rivaroxaban Therapy
title_fullStr Incomplete Resolution of Deep Vein Thromboses during Rivaroxaban Therapy
title_full_unstemmed Incomplete Resolution of Deep Vein Thromboses during Rivaroxaban Therapy
title_short Incomplete Resolution of Deep Vein Thromboses during Rivaroxaban Therapy
title_sort incomplete resolution of deep vein thromboses during rivaroxaban therapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554577/
https://www.ncbi.nlm.nih.gov/pubmed/28828188
http://dx.doi.org/10.1155/2017/3628127
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