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SynergyFinder: a web application for analyzing drug combination dose–response matrix data
Summary: Rational design of drug combinations has become a promising strategy to tackle the drug sensitivity and resistance problem in cancer treatment. To systematically evaluate the pre-clinical significance of pairwise drug combinations, functional screening assays that probe combination effects...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554616/ https://www.ncbi.nlm.nih.gov/pubmed/28379339 http://dx.doi.org/10.1093/bioinformatics/btx162 |
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author | Ianevski, Aleksandr He, Liye Aittokallio, Tero Tang, Jing |
author_facet | Ianevski, Aleksandr He, Liye Aittokallio, Tero Tang, Jing |
author_sort | Ianevski, Aleksandr |
collection | PubMed |
description | Summary: Rational design of drug combinations has become a promising strategy to tackle the drug sensitivity and resistance problem in cancer treatment. To systematically evaluate the pre-clinical significance of pairwise drug combinations, functional screening assays that probe combination effects in a dose–response matrix assay are commonly used. To facilitate the analysis of such drug combination experiments, we implemented a web application that uses key functions of R-package SynergyFinder, and provides not only the flexibility of using multiple synergy scoring models, but also a user-friendly interface for visualizing the drug combination landscapes in an interactive manner. Availability and Implementation: The SynergyFinder web application is freely accessible at https://synergyfinder.fimm.fi; The R-package and its source-code are freely available at http://bioconductor.org/packages/release/bioc/html/synergyfinder.html. |
format | Online Article Text |
id | pubmed-5554616 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-55546162017-08-13 SynergyFinder: a web application for analyzing drug combination dose–response matrix data Ianevski, Aleksandr He, Liye Aittokallio, Tero Tang, Jing Bioinformatics Applications Notes Summary: Rational design of drug combinations has become a promising strategy to tackle the drug sensitivity and resistance problem in cancer treatment. To systematically evaluate the pre-clinical significance of pairwise drug combinations, functional screening assays that probe combination effects in a dose–response matrix assay are commonly used. To facilitate the analysis of such drug combination experiments, we implemented a web application that uses key functions of R-package SynergyFinder, and provides not only the flexibility of using multiple synergy scoring models, but also a user-friendly interface for visualizing the drug combination landscapes in an interactive manner. Availability and Implementation: The SynergyFinder web application is freely accessible at https://synergyfinder.fimm.fi; The R-package and its source-code are freely available at http://bioconductor.org/packages/release/bioc/html/synergyfinder.html. Oxford University Press 2017-08-01 2017-04-07 /pmc/articles/PMC5554616/ /pubmed/28379339 http://dx.doi.org/10.1093/bioinformatics/btx162 Text en © The Author 2017. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Applications Notes Ianevski, Aleksandr He, Liye Aittokallio, Tero Tang, Jing SynergyFinder: a web application for analyzing drug combination dose–response matrix data |
title | SynergyFinder: a web application for analyzing drug combination dose–response matrix data |
title_full | SynergyFinder: a web application for analyzing drug combination dose–response matrix data |
title_fullStr | SynergyFinder: a web application for analyzing drug combination dose–response matrix data |
title_full_unstemmed | SynergyFinder: a web application for analyzing drug combination dose–response matrix data |
title_short | SynergyFinder: a web application for analyzing drug combination dose–response matrix data |
title_sort | synergyfinder: a web application for analyzing drug combination dose–response matrix data |
topic | Applications Notes |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554616/ https://www.ncbi.nlm.nih.gov/pubmed/28379339 http://dx.doi.org/10.1093/bioinformatics/btx162 |
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