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Induction of autophagy by sphingosine kinase 1 inhibitor PF-543 in head and neck squamous cell carcinoma cells

Sphingosine kinase 1 (SphK1) overexpressed in head and neck squamous cell carcinoma (SCC) regulates tumor growth. The effects of PF-543, a specific SphK1 inhibitor, on human SCC cells were examined. The proportion of viable cells after PF-543 treatment decreased in a time- and dose-dependent manner,...

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Detalles Bibliográficos
Autores principales:	Hamada, Masakazu, Kameyama, Hiroyasu, Iwai, Soichi, Yura, Yoshiaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554793/ https://www.ncbi.nlm.nih.gov/pubmed/29109864 http://dx.doi.org/10.1038/cddiscovery.2017.47

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