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Whole transcriptome data of zebrafish exposed to chronic dose of depleted uranium
The concentration of depleted uranium (DU) in the environment is expected to increase due to anthropogenic activities, posing potential risks on ecosystems. The effects of chronic exposure to DU at concentration close to the environmental standards (0.3–30 µg DU/L) are scarcely characterised. Genomi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554979/ https://www.ncbi.nlm.nih.gov/pubmed/28831411 http://dx.doi.org/10.1016/j.dib.2017.07.071 |
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author | Armant, Olivier Gombeau, Kewin Guillermin, Christelle Adam |
author_facet | Armant, Olivier Gombeau, Kewin Guillermin, Christelle Adam |
author_sort | Armant, Olivier |
collection | PubMed |
description | The concentration of depleted uranium (DU) in the environment is expected to increase due to anthropogenic activities, posing potential risks on ecosystems. The effects of chronic exposure to DU at concentration close to the environmental standards (0.3–30 µg DU/L) are scarcely characterised. Genomic alterations caused by low doses of pollutants can potentially propagate over generations, but how these effects may affect the health of the progeny remain uncertain for the vast majority of toxicants. The present dataset describes the transcriptomic effects of a chronic exposure to 20 µg DU/L during 10 days on adult zebrafish (Danio rerio) organs, the brain, the testis and the ovaries. The potential multigenerational effects of DU were assessed on the progeny of the adult exposed fish at the two-cells stage and after four days of development. We describe in this article the summary statistics of the differential gene expression analysis and focus on key molecular pathways affected by an exposure to a low concentration of DU. The data presented in this study supports the observation made in Armant et al. (2017) [1] (https://doi.org/10.1016/j.dib.2016.05.007) that DU can induce a molecular stress in both adult zebrafish and their progeny. The raw dataset has been deposited at the Gene Expression Omnibus (GEO) repository under the accession number GEO:GSE96603. |
format | Online Article Text |
id | pubmed-5554979 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-55549792017-08-22 Whole transcriptome data of zebrafish exposed to chronic dose of depleted uranium Armant, Olivier Gombeau, Kewin Guillermin, Christelle Adam Data Brief Environmental Science The concentration of depleted uranium (DU) in the environment is expected to increase due to anthropogenic activities, posing potential risks on ecosystems. The effects of chronic exposure to DU at concentration close to the environmental standards (0.3–30 µg DU/L) are scarcely characterised. Genomic alterations caused by low doses of pollutants can potentially propagate over generations, but how these effects may affect the health of the progeny remain uncertain for the vast majority of toxicants. The present dataset describes the transcriptomic effects of a chronic exposure to 20 µg DU/L during 10 days on adult zebrafish (Danio rerio) organs, the brain, the testis and the ovaries. The potential multigenerational effects of DU were assessed on the progeny of the adult exposed fish at the two-cells stage and after four days of development. We describe in this article the summary statistics of the differential gene expression analysis and focus on key molecular pathways affected by an exposure to a low concentration of DU. The data presented in this study supports the observation made in Armant et al. (2017) [1] (https://doi.org/10.1016/j.dib.2016.05.007) that DU can induce a molecular stress in both adult zebrafish and their progeny. The raw dataset has been deposited at the Gene Expression Omnibus (GEO) repository under the accession number GEO:GSE96603. Elsevier 2017-07-28 /pmc/articles/PMC5554979/ /pubmed/28831411 http://dx.doi.org/10.1016/j.dib.2017.07.071 Text en © 2017 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Environmental Science Armant, Olivier Gombeau, Kewin Guillermin, Christelle Adam Whole transcriptome data of zebrafish exposed to chronic dose of depleted uranium |
title | Whole transcriptome data of zebrafish exposed to chronic dose of depleted uranium |
title_full | Whole transcriptome data of zebrafish exposed to chronic dose of depleted uranium |
title_fullStr | Whole transcriptome data of zebrafish exposed to chronic dose of depleted uranium |
title_full_unstemmed | Whole transcriptome data of zebrafish exposed to chronic dose of depleted uranium |
title_short | Whole transcriptome data of zebrafish exposed to chronic dose of depleted uranium |
title_sort | whole transcriptome data of zebrafish exposed to chronic dose of depleted uranium |
topic | Environmental Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554979/ https://www.ncbi.nlm.nih.gov/pubmed/28831411 http://dx.doi.org/10.1016/j.dib.2017.07.071 |
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