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N-acetyl cysteine in ovulation induction of PCOS women underwent intrauterine insemination: An RCT

BACKGROUND: N-acetyl cysteine (NAC) was proposed as an adjuvant to clomiphene citrate for ovulation induction in patients with polycystic ovary syndrome (PCOS) without clomiphene citrate resistance. OBJECTIVE: To evaluate the effect of NAC on pregnancy rate in PCOS patients who were candidates for i...

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Autores principales: Behrouzi Lak, Tahereh, Hajshafiha, Masoomeh, Nanbakhsh, Fariba, Oshnouei, Sima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research and Clinical Center for Infertility 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555037/
https://www.ncbi.nlm.nih.gov/pubmed/28835936
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author Behrouzi Lak, Tahereh
Hajshafiha, Masoomeh
Nanbakhsh, Fariba
Oshnouei, Sima
author_facet Behrouzi Lak, Tahereh
Hajshafiha, Masoomeh
Nanbakhsh, Fariba
Oshnouei, Sima
author_sort Behrouzi Lak, Tahereh
collection PubMed
description BACKGROUND: N-acetyl cysteine (NAC) was proposed as an adjuvant to clomiphene citrate for ovulation induction in patients with polycystic ovary syndrome (PCOS) without clomiphene citrate resistance. OBJECTIVE: To evaluate the effect of NAC on pregnancy rate in PCOS patients who were candidates for intrauterine insemination. MATERIALS AND METHODS: In this randomized clinical trial, 97 PCOS women aged 18-38 years were enrolled in two groups, randomly. For the case group (n=49), NAC (1.2 gr)+ clomiphene citrate (100 mg) + letrozole (5mg) were prescribed daily from the third day of menstruation cycle for five days. The control group (n=48) had the same drug regimen without NAC. In order to follicular development, recombinant human follicle stimulating hormone (r-hFSH; Gonal-F®) was injected on days of 7-11 menstrual cycles in all participants. When the follicle size was 18mm or more, 10000 IU human chorionic gonadotropin was injected intramuscular and the intrauterine insemination was performed after 34-36 hr. RESULTS: There were not significant differences between study groups regarding mean endometrial thickness (p=0.14), the mean number of mature follicles (p=0.20), and the pregnancy rate (p=0.09). CONCLUSION: NAC is ineffective in inducing or augmenting ovulation in PCOS patients who were candidates for intrauterine insemination and cannot be recommended as an adjuvant to CC in such patients.
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spelling pubmed-55550372017-08-23 N-acetyl cysteine in ovulation induction of PCOS women underwent intrauterine insemination: An RCT Behrouzi Lak, Tahereh Hajshafiha, Masoomeh Nanbakhsh, Fariba Oshnouei, Sima Int J Reprod Biomed Original Article BACKGROUND: N-acetyl cysteine (NAC) was proposed as an adjuvant to clomiphene citrate for ovulation induction in patients with polycystic ovary syndrome (PCOS) without clomiphene citrate resistance. OBJECTIVE: To evaluate the effect of NAC on pregnancy rate in PCOS patients who were candidates for intrauterine insemination. MATERIALS AND METHODS: In this randomized clinical trial, 97 PCOS women aged 18-38 years were enrolled in two groups, randomly. For the case group (n=49), NAC (1.2 gr)+ clomiphene citrate (100 mg) + letrozole (5mg) were prescribed daily from the third day of menstruation cycle for five days. The control group (n=48) had the same drug regimen without NAC. In order to follicular development, recombinant human follicle stimulating hormone (r-hFSH; Gonal-F®) was injected on days of 7-11 menstrual cycles in all participants. When the follicle size was 18mm or more, 10000 IU human chorionic gonadotropin was injected intramuscular and the intrauterine insemination was performed after 34-36 hr. RESULTS: There were not significant differences between study groups regarding mean endometrial thickness (p=0.14), the mean number of mature follicles (p=0.20), and the pregnancy rate (p=0.09). CONCLUSION: NAC is ineffective in inducing or augmenting ovulation in PCOS patients who were candidates for intrauterine insemination and cannot be recommended as an adjuvant to CC in such patients. Research and Clinical Center for Infertility 2017-04-10 /pmc/articles/PMC5555037/ /pubmed/28835936 Text en https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Behrouzi Lak, Tahereh
Hajshafiha, Masoomeh
Nanbakhsh, Fariba
Oshnouei, Sima
N-acetyl cysteine in ovulation induction of PCOS women underwent intrauterine insemination: An RCT
title N-acetyl cysteine in ovulation induction of PCOS women underwent intrauterine insemination: An RCT
title_full N-acetyl cysteine in ovulation induction of PCOS women underwent intrauterine insemination: An RCT
title_fullStr N-acetyl cysteine in ovulation induction of PCOS women underwent intrauterine insemination: An RCT
title_full_unstemmed N-acetyl cysteine in ovulation induction of PCOS women underwent intrauterine insemination: An RCT
title_short N-acetyl cysteine in ovulation induction of PCOS women underwent intrauterine insemination: An RCT
title_sort n-acetyl cysteine in ovulation induction of pcos women underwent intrauterine insemination: an rct
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555037/
https://www.ncbi.nlm.nih.gov/pubmed/28835936
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