Disease-linked mutations in factor H reveal pivotal role of cofactor activity in self-surface–selective regulation of complement activation

Spontaneous activation enables the complement system to respond very rapidly to diverse threats. This activation is efficiently suppressed by complement factor H (CFH) on self-surfaces but not on foreign surfaces. The surface selectivity of CFH, a soluble protein containing 20 complement-control pro...

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Detalles Bibliográficos
Autores principales: Kerr, Heather, Wong, Edwin, Makou, Elisavet, Yang, Yi, Marchbank, Kevin, Kavanagh, David, Richards, Anna, Herbert, Andrew P., Barlow, Paul N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555194/
https://www.ncbi.nlm.nih.gov/pubmed/28637873
http://dx.doi.org/10.1074/jbc.M117.795088

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