Dysregulated Zn(2+) homeostasis impairs cardiac type-2 ryanodine receptor and mitsugumin 23 functions, leading to sarcoplasmic reticulum Ca(2+) leakage

Aberrant Zn(2+) homeostasis is associated with dysregulated intracellular Ca(2+) release, resulting in chronic heart failure. In the failing heart a small population of cardiac ryanodine receptors (RyR2) displays sub-conductance-state gating leading to Ca(2+) leakage from sarcoplasmic reticulum (SR)...

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Detalles Bibliográficos
Autores principales: Reilly-O'Donnell, Benedict, Robertson, Gavin B., Karumbi, Angela, McIntyre, Connor, Bal, Wojciech, Nishi, Miyuki, Takeshima, Hiroshi, Stewart, Alan J., Pitt, Samantha J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2017
Materias:
Membrane Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555195/
https://www.ncbi.nlm.nih.gov/pubmed/28630041
http://dx.doi.org/10.1074/jbc.M117.781708

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