A case of invasive aspergillosis in CGD patient successfully treated with Amphotericin B and INF-γ

BACKGROUND: Chronic granulomatous disease (CGD) is a rare disorder of phagocytes in which absence of superoxide and hydrogen peroxide production in phagocytes predisposes patients to bacterial and fungal infections. The most common fungal infections in these patients are caused by Aspergillus specie...

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Autores principales: Mamishi, Setareh, Zomorodian, Kamiar, Saadat, Farshid, Gerami-Shoar, Mohsen, Tarazooie, Bita, Siadati, Seyad Ahmad
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC555544/
https://www.ncbi.nlm.nih.gov/pubmed/15745454
http://dx.doi.org/10.1186/1476-0711-4-4
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author Mamishi, Setareh
Zomorodian, Kamiar
Saadat, Farshid
Gerami-Shoar, Mohsen
Tarazooie, Bita
Siadati, Seyad Ahmad
author_facet Mamishi, Setareh
Zomorodian, Kamiar
Saadat, Farshid
Gerami-Shoar, Mohsen
Tarazooie, Bita
Siadati, Seyad Ahmad
author_sort Mamishi, Setareh
collection PubMed
description BACKGROUND: Chronic granulomatous disease (CGD) is a rare disorder of phagocytes in which absence of superoxide and hydrogen peroxide production in phagocytes predisposes patients to bacterial and fungal infections. The most common fungal infections in these patients are caused by Aspergillus species. CASE PRESENTATION: Here, we describe Aspergillus osteomyelitis of the ribs and hepatic abscess in a 5-year-old boy. The patient was successfully treated with Amphotericin B and INF-γ. CONCLUSION: With respect to the high frequency of aspergillosis in the CGD patient, immune deficiency should be investigated in patients with invasive aspergillosis. Moreover, using antifungal drugs as prophylaxis can improve the quality of life in these patients.
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spelling pubmed-5555442005-03-25 A case of invasive aspergillosis in CGD patient successfully treated with Amphotericin B and INF-γ Mamishi, Setareh Zomorodian, Kamiar Saadat, Farshid Gerami-Shoar, Mohsen Tarazooie, Bita Siadati, Seyad Ahmad Ann Clin Microbiol Antimicrob Case Report BACKGROUND: Chronic granulomatous disease (CGD) is a rare disorder of phagocytes in which absence of superoxide and hydrogen peroxide production in phagocytes predisposes patients to bacterial and fungal infections. The most common fungal infections in these patients are caused by Aspergillus species. CASE PRESENTATION: Here, we describe Aspergillus osteomyelitis of the ribs and hepatic abscess in a 5-year-old boy. The patient was successfully treated with Amphotericin B and INF-γ. CONCLUSION: With respect to the high frequency of aspergillosis in the CGD patient, immune deficiency should be investigated in patients with invasive aspergillosis. Moreover, using antifungal drugs as prophylaxis can improve the quality of life in these patients. BioMed Central 2005-03-03 /pmc/articles/PMC555544/ /pubmed/15745454 http://dx.doi.org/10.1186/1476-0711-4-4 Text en Copyright © 2005 Mamishi et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Mamishi, Setareh
Zomorodian, Kamiar
Saadat, Farshid
Gerami-Shoar, Mohsen
Tarazooie, Bita
Siadati, Seyad Ahmad
A case of invasive aspergillosis in CGD patient successfully treated with Amphotericin B and INF-γ
title A case of invasive aspergillosis in CGD patient successfully treated with Amphotericin B and INF-γ
title_full A case of invasive aspergillosis in CGD patient successfully treated with Amphotericin B and INF-γ
title_fullStr A case of invasive aspergillosis in CGD patient successfully treated with Amphotericin B and INF-γ
title_full_unstemmed A case of invasive aspergillosis in CGD patient successfully treated with Amphotericin B and INF-γ
title_short A case of invasive aspergillosis in CGD patient successfully treated with Amphotericin B and INF-γ
title_sort case of invasive aspergillosis in cgd patient successfully treated with amphotericin b and inf-γ
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC555544/
https://www.ncbi.nlm.nih.gov/pubmed/15745454
http://dx.doi.org/10.1186/1476-0711-4-4
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