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ERK2 and JNK1 contribute to TNF-α-induced IL-8 expression in synovial fibroblasts

Tumor necrosis factor α (TNF-α) induces the expression and secretion of interleukin 8 (IL-8), which contributes to synovitis in rheumatoid arthritis (RA). To elucidate the mechanism of the onset of RA, we used synovial fibroblasts without autoimmune inflammatory diseases and investigated MAPK signal...

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Detalles Bibliográficos
Autores principales:	Namba, Shinichi, Nakano, Rei, Kitanaka, Taku, Kitanaka, Nanako, Nakayama, Tomohiro, Sugiya, Hiroshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555573/ https://www.ncbi.nlm.nih.gov/pubmed/28806729 http://dx.doi.org/10.1371/journal.pone.0182923

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