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Selective small-chemical inhibitors of protein arginine methyltransferase 5 with anti-lung cancer activity

Protein arginine methyltransferase 5 (PRMT5) plays critical roles in a wide variety of biological processes, including tumorigenesis. By screening a library of small chemical compounds, we identified eight compounds that selectively inhibit the PRMT5 enzymatic activity, with IC(50) values ranging fr...

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Detalles Bibliográficos
Autores principales:	Kong, Gui-Mei, Yu, Min, Gu, Zhongping, Chen, Zhi, Xu, Rui-Ming, O'Bryant, Deon, Wang, Zhengxin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555576/ https://www.ncbi.nlm.nih.gov/pubmed/28806746 http://dx.doi.org/10.1371/journal.pone.0181601

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