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Increasing creatine kinase activity protects against hypoxia / reoxygenation injury but not against anthracycline toxicity in vitro

The creatine kinase (CK) phosphagen system is fundamental to cellular energy homeostasis. Cardiomyocytes express three CK isoforms, namely the mitochondrial sarcomeric CKMT2 and the cytoplasmic CKM and CKB. We hypothesized that augmenting CK in vitro would preserve cell viability and function and so...

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Detalles Bibliográficos
Autores principales:	Zervou, Sevasti, Whittington, Hannah J., Ostrowski, Philip J., Cao, Fang, Tyler, Jack, Lake, Hannah A., Neubauer, Stefan, Lygate, Craig A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555628/ https://www.ncbi.nlm.nih.gov/pubmed/28806770 http://dx.doi.org/10.1371/journal.pone.0182994

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