Partial IGF-1 deficiency is sufficient to reduce heart contractibility, angiotensin II sensibility, and alter gene expression of structural and functional cardiac proteins

Circulating levels of IGF-1 may decrease under several circumstances like ageing, metabolic syndrome, and advanced cirrhosis. This reduction is associated with insulin resistance, dyslipidemia, progression to type 2 diabetes, and increased risk for cardiovascular diseases. However, underlying mechan...

Descripción completa

Detalles Bibliográficos
Autores principales: González-Guerra, José Luis, Castilla-Cortazar, Inma, Aguirre, Gabriel A., Muñoz, Úrsula, Martín-Estal, Irene, Ávila-Gallego, Elena, Granado, Miriam, Puche, Juan E., García-Villalón, Ángel Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555709/
https://www.ncbi.nlm.nih.gov/pubmed/28806738
http://dx.doi.org/10.1371/journal.pone.0181760

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555709/
https://www.ncbi.nlm.nih.gov/pubmed/28806738
http://dx.doi.org/10.1371/journal.pone.0181760

Ejemplares similares