Specific calpain inhibition protects kidney against inflammaging

Calpains are ubiquitous pro-inflammatory proteases, whose activity is controlled by calpastatin, their specific inhibitor. Transgenic mice over-expressing rabbit calpastatin (CalpTG) are protected against vascular remodelling and angiotensin II-dependent inflammation. We hypothesized that specific c...

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Detalles Bibliográficos
Autores principales: Hanouna, Guillaume, Mesnard, Laurent, Vandermeersch, Sophie, Perez, Joëlle, Placier, Sandrine, Haymann, Jean-Philippe, Campagne, Fabien, Moroch, Julien, Bataille, Aurélien, Baud, Laurent, Letavernier, Emmanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556007/
https://www.ncbi.nlm.nih.gov/pubmed/28808241
http://dx.doi.org/10.1038/s41598-017-07922-1

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