Targeting Apolipoprotein E/Amyloid β Binding by Peptoid CPO_Aβ17-21 P Ameliorates Alzheimer’s Disease Related Pathology and Cognitive Decline

Inheritance of the apolipoprotein E4 (apoE4) genotype has been identified as the major genetic risk factor for late onset Alzheimer’s disease (AD). Studies have shown that apoE, apoE4 in particular, binds to amyloid-β (Aβ) peptides at residues 12-28 of Aβ and this binding modulates Aβ accumulation a...

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Detalles Bibliográficos
Autores principales: Liu, Shan, Park, Shinae, Allington, Grant, Prelli, Frances, Sun, Yanjie, Martá-Ariza, Mitchell, Scholtzova, Henrieta, Biswas, Goutam, Brown, Bernard, Verghese, Philip B., Mehta, Pankaj D., Kwon, Yong-Uk, Wisniewski, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556019/
https://www.ncbi.nlm.nih.gov/pubmed/28808293
http://dx.doi.org/10.1038/s41598-017-08604-8

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