In silico analysis of Glanzmann variants of Calf-1 domain of α(IIb)β(3) integrin revealed dynamic allosteric effect

Integrin α(IIb)β(3) mediates platelet aggregation and thrombus formation. In a rare hereditary bleeding disorder, Glanzmann thrombasthenia (GT), α(IIb)β(3) expression / function are impaired. The impact of deleterious missense mutations on the complex structure remains unclear. Long independent mole...

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Detalles Bibliográficos
Autores principales: Goguet, Matthieu, Narwani, Tarun Jairaj, Petermann, Rachel, Jallu, Vincent, de Brevern, Alexandre G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556033/
https://www.ncbi.nlm.nih.gov/pubmed/28808266
http://dx.doi.org/10.1038/s41598-017-08408-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556033/
https://www.ncbi.nlm.nih.gov/pubmed/28808266
http://dx.doi.org/10.1038/s41598-017-08408-w

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