Cargando…

SpotOn: High Accuracy Identification of Protein-Protein Interface Hot-Spots

We present SpotOn, a web server to identify and classify interfacial residues as Hot-Spots (HS) and Null-Spots (NS). SpotON implements a robust algorithm with a demonstrated accuracy of 0.95 and sensitivity of 0.98 on an independent test set. The predictor was developed using an ensemble machine lea...

Descripción completa

Detalles Bibliográficos
Autores principales:	Moreira, Irina S., Koukos, Panagiotis I., Melo, Rita, Almeida, Jose G., Preto, Antonio J., Schaarschmidt, Joerg, Trellet, Mikael, Gümüş, Zeynep H., Costa, Joaquim, Bonvin, Alexandre M. J. J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556074/ https://www.ncbi.nlm.nih.gov/pubmed/28808256 http://dx.doi.org/10.1038/s41598-017-08321-2

Ejemplares similares

SPOTONE: Hot Spots on Protein Complexes with Extremely Randomized Trees via Sequence-Only Features
por: Preto, A. J., et al.
Publicado: (2020)

A Machine Learning Approach for Hot-Spot Detection at Protein-Protein Interfaces
por: Melo, Rita, et al.
Publicado: (2016)

Identification of hot spot residues at protein-protein interface
por: Li, Lei, et al.
Publicado: (2006)

HotSprint: database of computational hot spots in protein interfaces
por: Guney, Emre, et al.
Publicado: (2008)

HotPoint: hot spot prediction server for protein interfaces
por: Tuncbag, Nurcan, et al.
Publicado: (2010)

Predicting and Experimentally Validating Hot-Spot Residues at Protein–Protein Interfaces
por: Ibarra, Amaurys A., et al.
Publicado: (2019)

HotSpot Wizard: a web server for identification of hot spots in protein engineering
por: Pavelka, Antonin, et al.
Publicado: (2009)

Predictions of Hot Spot Residues at Protein-Protein Interfaces Using Support Vector Machines
por: Lise, Stefano, et al.
Publicado: (2011)

A semi-supervised boosting SVM for predicting hot spots at protein-protein Interfaces
por: Xu, Bin, et al.
Publicado: (2012)

Enhanced Prediction of Hot Spots at Protein-Protein Interfaces Using Extreme Gradient Boosting
por: Wang, Hao, et al.
Publicado: (2018)

PCRPi-DB: a database of computationally annotated hot spots in protein interfaces
por: Segura, Joan, et al.
Publicado: (2011)

MENSAdb: a thorough structural analysis of membrane protein dimers
por: Matos-Filipe, Pedro, et al.
Publicado: (2021)

Protein-protein interface hot spots prediction based on a hybrid feature selection strategy
por: Qiao, Yanhua, et al.
Publicado: (2018)

Performance of HADDOCK and a simple contact-based protein–ligand binding affinity predictor in the D3R Grand Challenge 2
por: Kurkcuoglu, Zeynep, et al.
Publicado: (2017)

Structural hot spots for the solubility of globular proteins
por: Ganesan, Ashok, et al.
Publicado: (2016)

Computationally identifying hot spots in protein-DNA binding interfaces using an ensemble approach
por: Pan, Yuliang, et al.
Publicado: (2020)

PCRPi: Presaging Critical Residues in Protein interfaces, a new computational tool to chart hot spots in protein interfaces
por: Assi, Salam A., et al.
Publicado: (2010)

Prediction of hot spot residues at protein-protein interfaces by combining machine learning and energy-based methods
por: Lise, Stefano, et al.
Publicado: (2009)

Spatial chemical conservation of hot spot interactions in protein-protein complexes
por: Shulman-Peleg, Alexandra, et al.
Publicado: (2007)

Hot spot prediction in protein-protein interactions by an ensemble system
por: Liu, Quanya, et al.
Publicado: (2018)

Identifying Malaria Hot Spots
por: White, Nicholas J
Publicado: (2017)

APIS: accurate prediction of hot spots in protein interfaces by combining protrusion index with solvent accessibility
por: Xia, Jun-Feng, et al.
Publicado: (2010)

XGBPRH: Prediction of Binding Hot Spots at Protein–RNA Interfaces Utilizing Extreme Gradient Boosting
por: Deng, Lei, et al.
Publicado: (2019)

KFC Server: interactive forecasting of protein interaction hot spots
por: Darnell, Steven J., et al.
Publicado: (2008)

Recognition and binding of mismatch repair proteins at an oncogenic hot spot
por: Edelbrock, Michael, et al.
Publicado: (2005)

Why is the H(3)(+) hot spot above Jupiter's Great Red Spot so hot?
por: Ray, L. C., et al.
Publicado: (2019)

PRODIGY-crystal: a web-tool for classification of biological interfaces in protein complexes
por: Jiménez-García, Brian, et al.
Publicado: (2019)

Presaging Critical Residues in Protein interfaces-Web Server (PCRPi-W): A Web Server to Chart Hot Spots in Protein Interfaces
por: Segura Mora, Joan, et al.
Publicado: (2010)

Identification of hot-spot residues in protein-protein interactions by computational docking
por: Grosdidier, Solène, et al.
Publicado: (2008)

‘Double water exclusion’: a hypothesis refining the O-ring theory for the hot spots at protein interfaces
por: Li, Jinyan, et al.
Publicado: (2009)

Biodiversity hot spot on a hot spot: novel extremophile diversity in Hawaiian fumaroles
por: Wall, Kate, et al.
Publicado: (2015)

Probing binding hot spots at protein–RNA recognition sites
por: Barik, Amita, et al.
Publicado: (2016)

The bud tip is the cellular hot spot of protein secretion in yeasts
por: Puxbaum, Verena, et al.
Publicado: (2016)

A Unified Conformational Selection and Induced Fit Approach to Protein-Peptide Docking
por: Trellet, Mikael, et al.
Publicado: (2013)

Intraoperative Temperature Monitoring with Zero Heat Flux Technology (3M SpotOn Sensor) in Comparison with Tympanic and Oesophageal Temperature and Hypotermia Risk Factors: An Observational Study
por: Aksu Erdost, Hale, et al.
Publicado: (2021)

Hot spots discussed at Bonn
Publicado: (1979)

DESY: Hot spots in the nucleon?
Publicado: (1990)

Hot spots discussed at Bonn
por: Weiner, Richard M
Publicado: (1979)

Anatomy of mouse recombination hot spots
por: Wu, Zhen K., et al.
Publicado: (2010)

Yellowstone Hot Springs are Organic Chemodiversity Hot Spots
por: Gonsior, Michael, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_8665h79phlb9ant1rr645rigli