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Ultrasonic evaluation of renal cortex arterial area enables differentiation between hypertensive and glomerulonephritis-related chronic kidney disease

PURPOSE: Identifying the primary etiology of cardio-renal syndrome in a timely manner remains an ongoing challenge in nephrology. We hypothesized that hypertensive kidney damage can be distinguished from chronic glomerulonephritis at an early stage of chronic kidney disease (CKD) using ultrasound (U...

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Autores principales: Lubas, Arkadiusz, Kade, Grzegorz, Ryczek, Robert, Banasiak, Piotr, Dyrla, Przemysław, Szamotulska, Katarzyna, Schneditz, Daniel, Niemczyk, Stanisław
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556137/
https://www.ncbi.nlm.nih.gov/pubmed/28573489
http://dx.doi.org/10.1007/s11255-017-1634-7
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author Lubas, Arkadiusz
Kade, Grzegorz
Ryczek, Robert
Banasiak, Piotr
Dyrla, Przemysław
Szamotulska, Katarzyna
Schneditz, Daniel
Niemczyk, Stanisław
author_facet Lubas, Arkadiusz
Kade, Grzegorz
Ryczek, Robert
Banasiak, Piotr
Dyrla, Przemysław
Szamotulska, Katarzyna
Schneditz, Daniel
Niemczyk, Stanisław
author_sort Lubas, Arkadiusz
collection PubMed
description PURPOSE: Identifying the primary etiology of cardio-renal syndrome in a timely manner remains an ongoing challenge in nephrology. We hypothesized that hypertensive kidney damage can be distinguished from chronic glomerulonephritis at an early stage of chronic kidney disease (CKD) using ultrasound (US) Doppler sonography. METHODS: Fifty-six males (age 54 ± 15, BMI 28.3 ± 3.5 kg/m(2)) with hypertension and stable CKD at stages 2–4 [38 with essential hypertension (HT-CKD); 18 with glomerulonephritis (GN-CKD)] were studied. Blood tests, UACR, echocardiography, ABPM, carotid IMT, and an ultrasound dynamic tissue perfusion measurement (DTPM) of the renal cortex were performed. RESULTS: HT-CKD patients had reduced proximal renal cortex perfusion as well as reduced total and proximal renal cortex arterial area. Proximal renal cortex arterial area ≤0.149 cm(2) identified hypertension-related CKD with a sensitivity of 71% and a specificity of 78% (AUC 0.753, p < 0.001). CONCLUSIONS: Evidence of diminished arterial vascularity or perfusion of renal proximal cortex, both derived from US Doppler, could be helpful in differentiating hypertensive nephropathy from glomerulonephritis-related CKD.
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spelling pubmed-55561372017-08-28 Ultrasonic evaluation of renal cortex arterial area enables differentiation between hypertensive and glomerulonephritis-related chronic kidney disease Lubas, Arkadiusz Kade, Grzegorz Ryczek, Robert Banasiak, Piotr Dyrla, Przemysław Szamotulska, Katarzyna Schneditz, Daniel Niemczyk, Stanisław Int Urol Nephrol Nephrology - Original Paper PURPOSE: Identifying the primary etiology of cardio-renal syndrome in a timely manner remains an ongoing challenge in nephrology. We hypothesized that hypertensive kidney damage can be distinguished from chronic glomerulonephritis at an early stage of chronic kidney disease (CKD) using ultrasound (US) Doppler sonography. METHODS: Fifty-six males (age 54 ± 15, BMI 28.3 ± 3.5 kg/m(2)) with hypertension and stable CKD at stages 2–4 [38 with essential hypertension (HT-CKD); 18 with glomerulonephritis (GN-CKD)] were studied. Blood tests, UACR, echocardiography, ABPM, carotid IMT, and an ultrasound dynamic tissue perfusion measurement (DTPM) of the renal cortex were performed. RESULTS: HT-CKD patients had reduced proximal renal cortex perfusion as well as reduced total and proximal renal cortex arterial area. Proximal renal cortex arterial area ≤0.149 cm(2) identified hypertension-related CKD with a sensitivity of 71% and a specificity of 78% (AUC 0.753, p < 0.001). CONCLUSIONS: Evidence of diminished arterial vascularity or perfusion of renal proximal cortex, both derived from US Doppler, could be helpful in differentiating hypertensive nephropathy from glomerulonephritis-related CKD. Springer Netherlands 2017-06-01 2017 /pmc/articles/PMC5556137/ /pubmed/28573489 http://dx.doi.org/10.1007/s11255-017-1634-7 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Nephrology - Original Paper
Lubas, Arkadiusz
Kade, Grzegorz
Ryczek, Robert
Banasiak, Piotr
Dyrla, Przemysław
Szamotulska, Katarzyna
Schneditz, Daniel
Niemczyk, Stanisław
Ultrasonic evaluation of renal cortex arterial area enables differentiation between hypertensive and glomerulonephritis-related chronic kidney disease
title Ultrasonic evaluation of renal cortex arterial area enables differentiation between hypertensive and glomerulonephritis-related chronic kidney disease
title_full Ultrasonic evaluation of renal cortex arterial area enables differentiation between hypertensive and glomerulonephritis-related chronic kidney disease
title_fullStr Ultrasonic evaluation of renal cortex arterial area enables differentiation between hypertensive and glomerulonephritis-related chronic kidney disease
title_full_unstemmed Ultrasonic evaluation of renal cortex arterial area enables differentiation between hypertensive and glomerulonephritis-related chronic kidney disease
title_short Ultrasonic evaluation of renal cortex arterial area enables differentiation between hypertensive and glomerulonephritis-related chronic kidney disease
title_sort ultrasonic evaluation of renal cortex arterial area enables differentiation between hypertensive and glomerulonephritis-related chronic kidney disease
topic Nephrology - Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556137/
https://www.ncbi.nlm.nih.gov/pubmed/28573489
http://dx.doi.org/10.1007/s11255-017-1634-7
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