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A new diagnostic marker for differentiating multicentric gliomas from multiple intracranial diffuse large B-cell lymphomas on (18)F-FDG PET images
Intracranial gliomas and lymphomas may share similar radiological manifestations, while the treatment strategies for them are different. The aim of the study was to investigate the diagnostic value of fluorine-18-fluoro-2-deoxy-D-glucose ((18)F-FDG) positron emission computed tomography (PET) for di...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556232/ https://www.ncbi.nlm.nih.gov/pubmed/28796066 http://dx.doi.org/10.1097/MD.0000000000007756 |
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author | Wang, Kai Zhao, Xiaobin Chen, Qian Fan, Di Qiao, Zhen Lin, Song Jiang, Tao Dai, Jianping Ai, Lin |
author_facet | Wang, Kai Zhao, Xiaobin Chen, Qian Fan, Di Qiao, Zhen Lin, Song Jiang, Tao Dai, Jianping Ai, Lin |
author_sort | Wang, Kai |
collection | PubMed |
description | Intracranial gliomas and lymphomas may share similar radiological manifestations, while the treatment strategies for them are different. The aim of the study was to investigate the diagnostic value of fluorine-18-fluoro-2-deoxy-D-glucose ((18)F-FDG) positron emission computed tomography (PET) for differentiation of multicentric gliomas and intracranial multiple diffuse large B-cell lymphomas (DLBCLs) as a study of diagnostic accuracy. A total of 32 patients with multiple intracranial tumors visualized on contrast-enhanced magnetic resonance imaging (MRI) were retrospectively evaluated. Histopathological findings confirmed multicentric gliomas and multiple DLBCLs in 17 and 15 patients, respectively. All patients underwent (18)F-FDG PET with or without (11)C-methionine PET. Maximum standardized uptake values (SUV(max)) and tumor-to-normal tissue (T/N) ratios were compared between the 2 tumors. The diagnostic value of (18)F-FDG PET for differentiating multicentric gliomas from multiple DLBCLs was evaluated by receiver operating characteristic (ROC) analysis. The SUV(max) of multiple DLBCLs was significantly higher than that of multicentric gliomas (P = .009). However, the percentage of maximum difference-value of SUV(max) (or T/N ratio) of multiple DLBCLs was significant lower than that of multicentric gliomas (P < .001). The ROC curve demonstrated that the percentage of maximum difference-value of SUV(max) (or T/N ratio) on (18)F-FDG PET images could effectively differentiate multicentric gliomas from multiple DLBCLs, with a cut-off value of 44.4%, sensitivity of 64.7%, and specificity of 100% (P < .001). Percentage of maximum difference-value of SUV(max) (or T/N ratio) on (18)F-FDG PET images might be a potential indicator for distinguishing multicentric gliomas from intracranial multiple DLBCLs, which might help determine the treatment strategy. |
format | Online Article Text |
id | pubmed-5556232 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-55562322017-08-25 A new diagnostic marker for differentiating multicentric gliomas from multiple intracranial diffuse large B-cell lymphomas on (18)F-FDG PET images Wang, Kai Zhao, Xiaobin Chen, Qian Fan, Di Qiao, Zhen Lin, Song Jiang, Tao Dai, Jianping Ai, Lin Medicine (Baltimore) 4100 Intracranial gliomas and lymphomas may share similar radiological manifestations, while the treatment strategies for them are different. The aim of the study was to investigate the diagnostic value of fluorine-18-fluoro-2-deoxy-D-glucose ((18)F-FDG) positron emission computed tomography (PET) for differentiation of multicentric gliomas and intracranial multiple diffuse large B-cell lymphomas (DLBCLs) as a study of diagnostic accuracy. A total of 32 patients with multiple intracranial tumors visualized on contrast-enhanced magnetic resonance imaging (MRI) were retrospectively evaluated. Histopathological findings confirmed multicentric gliomas and multiple DLBCLs in 17 and 15 patients, respectively. All patients underwent (18)F-FDG PET with or without (11)C-methionine PET. Maximum standardized uptake values (SUV(max)) and tumor-to-normal tissue (T/N) ratios were compared between the 2 tumors. The diagnostic value of (18)F-FDG PET for differentiating multicentric gliomas from multiple DLBCLs was evaluated by receiver operating characteristic (ROC) analysis. The SUV(max) of multiple DLBCLs was significantly higher than that of multicentric gliomas (P = .009). However, the percentage of maximum difference-value of SUV(max) (or T/N ratio) of multiple DLBCLs was significant lower than that of multicentric gliomas (P < .001). The ROC curve demonstrated that the percentage of maximum difference-value of SUV(max) (or T/N ratio) on (18)F-FDG PET images could effectively differentiate multicentric gliomas from multiple DLBCLs, with a cut-off value of 44.4%, sensitivity of 64.7%, and specificity of 100% (P < .001). Percentage of maximum difference-value of SUV(max) (or T/N ratio) on (18)F-FDG PET images might be a potential indicator for distinguishing multicentric gliomas from intracranial multiple DLBCLs, which might help determine the treatment strategy. Wolters Kluwer Health 2017-08-11 /pmc/articles/PMC5556232/ /pubmed/28796066 http://dx.doi.org/10.1097/MD.0000000000007756 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | 4100 Wang, Kai Zhao, Xiaobin Chen, Qian Fan, Di Qiao, Zhen Lin, Song Jiang, Tao Dai, Jianping Ai, Lin A new diagnostic marker for differentiating multicentric gliomas from multiple intracranial diffuse large B-cell lymphomas on (18)F-FDG PET images |
title | A new diagnostic marker for differentiating multicentric gliomas from multiple intracranial diffuse large B-cell lymphomas on (18)F-FDG PET images |
title_full | A new diagnostic marker for differentiating multicentric gliomas from multiple intracranial diffuse large B-cell lymphomas on (18)F-FDG PET images |
title_fullStr | A new diagnostic marker for differentiating multicentric gliomas from multiple intracranial diffuse large B-cell lymphomas on (18)F-FDG PET images |
title_full_unstemmed | A new diagnostic marker for differentiating multicentric gliomas from multiple intracranial diffuse large B-cell lymphomas on (18)F-FDG PET images |
title_short | A new diagnostic marker for differentiating multicentric gliomas from multiple intracranial diffuse large B-cell lymphomas on (18)F-FDG PET images |
title_sort | new diagnostic marker for differentiating multicentric gliomas from multiple intracranial diffuse large b-cell lymphomas on (18)f-fdg pet images |
topic | 4100 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556232/ https://www.ncbi.nlm.nih.gov/pubmed/28796066 http://dx.doi.org/10.1097/MD.0000000000007756 |
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