Cargando…

Lack of Breastfeeding History in Parous Women with Inflammatory Breast Cancer Predicts Poor Disease-Free Survival

Purpose: Breastfeeding alters the breast microenvironment, and several lines of evidence suggest the breast microenvironment contributes to the clinical phenotype of inflammatory breast cancer. We investigated breastfeeding history as a modifier of locoregional recurrence (LRR), distant metastasis (...

Descripción completa

Detalles Bibliográficos
Autores principales: Stecklein, Shane R., Reddy, Jay P., Wolfe, Adam R., Lopez, Mirtha S., Fouad, Tamer M., Debeb, Bisrat G., Ueno, Naoto T., Brewster, Abenaa M., Woodward, Wendy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556634/
https://www.ncbi.nlm.nih.gov/pubmed/28819368
http://dx.doi.org/10.7150/jca.20095
_version_ 1783257102490271744
author Stecklein, Shane R.
Reddy, Jay P.
Wolfe, Adam R.
Lopez, Mirtha S.
Fouad, Tamer M.
Debeb, Bisrat G.
Ueno, Naoto T.
Brewster, Abenaa M.
Woodward, Wendy A.
author_facet Stecklein, Shane R.
Reddy, Jay P.
Wolfe, Adam R.
Lopez, Mirtha S.
Fouad, Tamer M.
Debeb, Bisrat G.
Ueno, Naoto T.
Brewster, Abenaa M.
Woodward, Wendy A.
author_sort Stecklein, Shane R.
collection PubMed
description Purpose: Breastfeeding alters the breast microenvironment, and several lines of evidence suggest the breast microenvironment contributes to the clinical phenotype of inflammatory breast cancer. We investigated breastfeeding history as a modifier of locoregional recurrence (LRR), distant metastasis (DM), disease-free survival (DFS), and overall survival (OS) in parous women with inflammatory breast cancer. Methods: Parous women with inflammatory breast cancer were identified from a prospective registry at The University of Texas MD Anderson Cancer Center. We compared patient and tumor characteristics, LRR, DM, DFS, and OS patients with (BF+) and without (BF-) a history of breastfeeding. Results: Eighty-two patients were included. At a median follow-up of 50 months, BF+ patients had significantly lower risk of LRR (9.0% vs. 23.6%; p=0.01), a lower risk of DM (26.8% vs. 53.8%; p=0.008), and better DFS (73.1% vs. 48.1%; p=0.006) than BF- patients. On multivariate analysis, BF+ history was associated with significantly lower risk of DM (hazard ratio 0.38, 95% confidence interval 0.15-0.97; p=0.04) and better DFS (hazard ratio 0.37, 95% confidence interval 0.15-0.93; p=0.04) after adjusting for established predictive and prognostic variables. The prognostic significance of breastfeeding may be most pronounced in women with triple-negative IBC. Conclusion: A lack of breastfeeding history in parous women with inflammatory breast cancer may predict worse prognosis. We speculate that breastfeeding-induced alterations in the breast microenvironment may alter the aggressiveness of inflammatory breast cancer.
format Online
Article
Text
id pubmed-5556634
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Ivyspring International Publisher
record_format MEDLINE/PubMed
spelling pubmed-55566342017-08-17 Lack of Breastfeeding History in Parous Women with Inflammatory Breast Cancer Predicts Poor Disease-Free Survival Stecklein, Shane R. Reddy, Jay P. Wolfe, Adam R. Lopez, Mirtha S. Fouad, Tamer M. Debeb, Bisrat G. Ueno, Naoto T. Brewster, Abenaa M. Woodward, Wendy A. J Cancer Research Paper Purpose: Breastfeeding alters the breast microenvironment, and several lines of evidence suggest the breast microenvironment contributes to the clinical phenotype of inflammatory breast cancer. We investigated breastfeeding history as a modifier of locoregional recurrence (LRR), distant metastasis (DM), disease-free survival (DFS), and overall survival (OS) in parous women with inflammatory breast cancer. Methods: Parous women with inflammatory breast cancer were identified from a prospective registry at The University of Texas MD Anderson Cancer Center. We compared patient and tumor characteristics, LRR, DM, DFS, and OS patients with (BF+) and without (BF-) a history of breastfeeding. Results: Eighty-two patients were included. At a median follow-up of 50 months, BF+ patients had significantly lower risk of LRR (9.0% vs. 23.6%; p=0.01), a lower risk of DM (26.8% vs. 53.8%; p=0.008), and better DFS (73.1% vs. 48.1%; p=0.006) than BF- patients. On multivariate analysis, BF+ history was associated with significantly lower risk of DM (hazard ratio 0.38, 95% confidence interval 0.15-0.97; p=0.04) and better DFS (hazard ratio 0.37, 95% confidence interval 0.15-0.93; p=0.04) after adjusting for established predictive and prognostic variables. The prognostic significance of breastfeeding may be most pronounced in women with triple-negative IBC. Conclusion: A lack of breastfeeding history in parous women with inflammatory breast cancer may predict worse prognosis. We speculate that breastfeeding-induced alterations in the breast microenvironment may alter the aggressiveness of inflammatory breast cancer. Ivyspring International Publisher 2017-07-01 /pmc/articles/PMC5556634/ /pubmed/28819368 http://dx.doi.org/10.7150/jca.20095 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Stecklein, Shane R.
Reddy, Jay P.
Wolfe, Adam R.
Lopez, Mirtha S.
Fouad, Tamer M.
Debeb, Bisrat G.
Ueno, Naoto T.
Brewster, Abenaa M.
Woodward, Wendy A.
Lack of Breastfeeding History in Parous Women with Inflammatory Breast Cancer Predicts Poor Disease-Free Survival
title Lack of Breastfeeding History in Parous Women with Inflammatory Breast Cancer Predicts Poor Disease-Free Survival
title_full Lack of Breastfeeding History in Parous Women with Inflammatory Breast Cancer Predicts Poor Disease-Free Survival
title_fullStr Lack of Breastfeeding History in Parous Women with Inflammatory Breast Cancer Predicts Poor Disease-Free Survival
title_full_unstemmed Lack of Breastfeeding History in Parous Women with Inflammatory Breast Cancer Predicts Poor Disease-Free Survival
title_short Lack of Breastfeeding History in Parous Women with Inflammatory Breast Cancer Predicts Poor Disease-Free Survival
title_sort lack of breastfeeding history in parous women with inflammatory breast cancer predicts poor disease-free survival
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556634/
https://www.ncbi.nlm.nih.gov/pubmed/28819368
http://dx.doi.org/10.7150/jca.20095
work_keys_str_mv AT steckleinshaner lackofbreastfeedinghistoryinparouswomenwithinflammatorybreastcancerpredictspoordiseasefreesurvival
AT reddyjayp lackofbreastfeedinghistoryinparouswomenwithinflammatorybreastcancerpredictspoordiseasefreesurvival
AT wolfeadamr lackofbreastfeedinghistoryinparouswomenwithinflammatorybreastcancerpredictspoordiseasefreesurvival
AT lopezmirthas lackofbreastfeedinghistoryinparouswomenwithinflammatorybreastcancerpredictspoordiseasefreesurvival
AT fouadtamerm lackofbreastfeedinghistoryinparouswomenwithinflammatorybreastcancerpredictspoordiseasefreesurvival
AT debebbisratg lackofbreastfeedinghistoryinparouswomenwithinflammatorybreastcancerpredictspoordiseasefreesurvival
AT uenonaotot lackofbreastfeedinghistoryinparouswomenwithinflammatorybreastcancerpredictspoordiseasefreesurvival
AT brewsterabenaam lackofbreastfeedinghistoryinparouswomenwithinflammatorybreastcancerpredictspoordiseasefreesurvival
AT woodwardwendya lackofbreastfeedinghistoryinparouswomenwithinflammatorybreastcancerpredictspoordiseasefreesurvival