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HIF is not essential for suppression of experimental tumor growth by mTOR inhibition

The Hypoxia Inducible Transcription Factor (HIF) is the master regulator of cellular response to hypoxic adaptation. Solid tumors inevitably harbour hypoxic regions with subsequent stabilization and activation of HIF and HIF target genes due to poor vascularization and rapid growth. The mammalian ta...

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Detalles Bibliográficos
Autores principales:	Knaup, Karl X., Guenther, Regina, Stoeckert, Johanna, Monti, Juliana M., Eckardt, Kai-Uwe, Wiesener, Michael S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556644/ https://www.ncbi.nlm.nih.gov/pubmed/28819378 http://dx.doi.org/10.7150/jca.16486

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