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Hypoxia-inducible factor-1 alpha Correlates with Tumor-Associated Macrophages Infiltration, Influences Survival of Gastric Cancer Patients
Background: Hypoxia was a common feature for accelerating tumor metastasis by both inducting epithelial-mesenchymal transition (EMT) of tumor cells and polarization of tumor-associated macrophages (TAMs). The association and roles between hypoxia, EMT and TAMs in the biological behavior of gastric c...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556645/ https://www.ncbi.nlm.nih.gov/pubmed/28819379 http://dx.doi.org/10.7150/jca.19057 |
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author | Zhang, Wei-jie Chen, Cheng Zhou, Zhi-hua Gao, Shan-ting Tee, Teong Jin Yang, Liu-qing Xu, Yuan-yuan Pang, Tao-hong Xu, Xin-yun Sun, Qi Feng, Min Wang, Hao Lu, Chun-lei Wu, Guo-zhong Wu, Sheng Guan, Wen-xian Xu, Gui-fang |
author_facet | Zhang, Wei-jie Chen, Cheng Zhou, Zhi-hua Gao, Shan-ting Tee, Teong Jin Yang, Liu-qing Xu, Yuan-yuan Pang, Tao-hong Xu, Xin-yun Sun, Qi Feng, Min Wang, Hao Lu, Chun-lei Wu, Guo-zhong Wu, Sheng Guan, Wen-xian Xu, Gui-fang |
author_sort | Zhang, Wei-jie |
collection | PubMed |
description | Background: Hypoxia was a common feature for accelerating tumor metastasis by both inducting epithelial-mesenchymal transition (EMT) of tumor cells and polarization of tumor-associated macrophages (TAMs). The association and roles between hypoxia, EMT and TAMs in the biological behavior of gastric cancer (GC) for the time being recurrence is unclear. Material and methods: hypoixa by expression of hypoxia-inducible factor-1 alpha (HIF-1α), polarized functional status of infiltrated TAMs by immunohistochemical staining of CD68 and CD163, and the expression of E-cadherin as EMT property had been evaluated in 236 patients consecutive with histologically confirmed GC. Clinical significance was assessed for all these patients. Results: High expression of HIF-1α was found in patients with aggressive features, especially for recurrent patients. High infiltration of TAMs and abnormal expression of EMT-marker were also related to aggressive characteristics and predicted poor prognosis in GC. Meanwwhile, there existed a significant correlation among expression of HIF-1α, infiltration of TAMs and EMT marker in GC tissues. Multivariate Cox analysis revealed that high expression of HIF-1α combined TAMs infiltration were independent prognostic factors for disease-specific survival rate. Conclusion: HIF-1α is an unfavorable indicator for prognosis, may promote tumor progression through the induction of EMT and establishment of a pro-tumor immunosuppressive microenvironment. Further investigation into the therapeutic effects of blocking hypoxia is possible a potential strategy for GC treatment. |
format | Online Article Text |
id | pubmed-5556645 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-55566452017-08-17 Hypoxia-inducible factor-1 alpha Correlates with Tumor-Associated Macrophages Infiltration, Influences Survival of Gastric Cancer Patients Zhang, Wei-jie Chen, Cheng Zhou, Zhi-hua Gao, Shan-ting Tee, Teong Jin Yang, Liu-qing Xu, Yuan-yuan Pang, Tao-hong Xu, Xin-yun Sun, Qi Feng, Min Wang, Hao Lu, Chun-lei Wu, Guo-zhong Wu, Sheng Guan, Wen-xian Xu, Gui-fang J Cancer Research Paper Background: Hypoxia was a common feature for accelerating tumor metastasis by both inducting epithelial-mesenchymal transition (EMT) of tumor cells and polarization of tumor-associated macrophages (TAMs). The association and roles between hypoxia, EMT and TAMs in the biological behavior of gastric cancer (GC) for the time being recurrence is unclear. Material and methods: hypoixa by expression of hypoxia-inducible factor-1 alpha (HIF-1α), polarized functional status of infiltrated TAMs by immunohistochemical staining of CD68 and CD163, and the expression of E-cadherin as EMT property had been evaluated in 236 patients consecutive with histologically confirmed GC. Clinical significance was assessed for all these patients. Results: High expression of HIF-1α was found in patients with aggressive features, especially for recurrent patients. High infiltration of TAMs and abnormal expression of EMT-marker were also related to aggressive characteristics and predicted poor prognosis in GC. Meanwwhile, there existed a significant correlation among expression of HIF-1α, infiltration of TAMs and EMT marker in GC tissues. Multivariate Cox analysis revealed that high expression of HIF-1α combined TAMs infiltration were independent prognostic factors for disease-specific survival rate. Conclusion: HIF-1α is an unfavorable indicator for prognosis, may promote tumor progression through the induction of EMT and establishment of a pro-tumor immunosuppressive microenvironment. Further investigation into the therapeutic effects of blocking hypoxia is possible a potential strategy for GC treatment. Ivyspring International Publisher 2017-07-02 /pmc/articles/PMC5556645/ /pubmed/28819379 http://dx.doi.org/10.7150/jca.19057 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Research Paper Zhang, Wei-jie Chen, Cheng Zhou, Zhi-hua Gao, Shan-ting Tee, Teong Jin Yang, Liu-qing Xu, Yuan-yuan Pang, Tao-hong Xu, Xin-yun Sun, Qi Feng, Min Wang, Hao Lu, Chun-lei Wu, Guo-zhong Wu, Sheng Guan, Wen-xian Xu, Gui-fang Hypoxia-inducible factor-1 alpha Correlates with Tumor-Associated Macrophages Infiltration, Influences Survival of Gastric Cancer Patients |
title | Hypoxia-inducible factor-1 alpha Correlates with Tumor-Associated Macrophages Infiltration, Influences Survival of Gastric Cancer Patients |
title_full | Hypoxia-inducible factor-1 alpha Correlates with Tumor-Associated Macrophages Infiltration, Influences Survival of Gastric Cancer Patients |
title_fullStr | Hypoxia-inducible factor-1 alpha Correlates with Tumor-Associated Macrophages Infiltration, Influences Survival of Gastric Cancer Patients |
title_full_unstemmed | Hypoxia-inducible factor-1 alpha Correlates with Tumor-Associated Macrophages Infiltration, Influences Survival of Gastric Cancer Patients |
title_short | Hypoxia-inducible factor-1 alpha Correlates with Tumor-Associated Macrophages Infiltration, Influences Survival of Gastric Cancer Patients |
title_sort | hypoxia-inducible factor-1 alpha correlates with tumor-associated macrophages infiltration, influences survival of gastric cancer patients |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556645/ https://www.ncbi.nlm.nih.gov/pubmed/28819379 http://dx.doi.org/10.7150/jca.19057 |
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