Cargando…

Phase II Trial of Adjuvant Immunotherapy with Autologous Tumor-derived Gp96 Vaccination in Patients with Gastric Cancer

Background/Aims: Autologous, tumor-derived, heat shock protein gp96 peptide complexes have antitumor potential. We conducted the first Phase II trial to evaluate the safety and efficacy of gp96 vaccination in adjuvant settings for patients with gastric cancer. Methods: We enrolled 73 consecutive pat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Kecheng, Peng, Zheng, Huang, Xiaohui, Qiao, Zhi, Wang, Xinxin, Wang, Ning, Xi, Hongqing, Cui, Jianxin, Gao, Yunhe, Huang, Xijian, Gao, Hua, Wei, Bo, Chen, Lin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556646/ https://www.ncbi.nlm.nih.gov/pubmed/28819380 http://dx.doi.org/10.7150/jca.18946

Ejemplares similares

Diagnostic and prognostic value of circulating tumor DNA in gastric cancer: a meta-analysis
por: Gao, Yunhe, et al.
Publicado: (2016)

Defining the impact of platelet-to-lymphocyte ratio on patient survival with gastric neuroendocrine neoplasm: a retrospective cohort analysis
por: Liang, Wenquan, et al.
Publicado: (2022)

Prolonged postoperative ileus in gastric surgery: Is there any difference between laparoscopic and open surgery?
por: Liang, Wenquan, et al.
Publicado: (2019)

Evaluation of hepatectomy and palliative local treatments for gastric cancer patients with liver metastases: a propensity score matching analysis
por: Li, Jiyang, et al.
Publicado: (2017)

Association of thymidylate synthase expression and clinical outcomes of gastric cancer patients treated with fluoropyrimidine-based chemotherapy: a meta-analysis
por: Gao, Yunhe, et al.
Publicado: (2016)

Robot-Assisted Versus Laparoscopy-Assisted Proximal Gastrectomy for Early Gastric Cancer in the Upper Location: Comparison of Oncological Outcomes, Surgical Stress, and Nutritional Status
por: Zhang, Kecheng, et al.
Publicado: (2018)

Ring finger protein 43 associates with gastric cancer progression and attenuates the stemness of gastric cancer stem-like cells via the Wnt-β/catenin signaling pathway
por: Gao, Yunhe, et al.
Publicado: (2017)

Genome-Wide lncRNA Microarray Profiling Identifies Novel Circulating lncRNAs for Detection of Gastric Cancer
por: Zhang, Kecheng, et al.
Publicado: (2017)

Tumor deposit serves as a prognostic marker in gastric cancer: A propensity score‐matched analysis comparing survival outcomes
por: Wenquan, Liang, et al.
Publicado: (2020)

GP96: safeguarding Treg
por: Zhang, Yongliang, et al.
Publicado: (2015)

Stearoyl-CoA-desaturase-1 regulates gastric cancer stem-like properties and promotes tumour metastasis via Hippo/YAP pathway
por: Gao, Yunhe, et al.
Publicado: (2020)

Gp96 Peptide Antagonist gp96-II Confers Therapeutic Effects in Murine Intestinal Inflammation
por: Nold-Petry, Claudia A., et al.
Publicado: (2017)

Association Between Liquid Biopsy and Prognosis of Gastric Cancer Patients: A Systematic Review and Meta-Analysis
por: Gao, Yunhe, et al.
Publicado: (2019)

Resection of Noncontrast-Enhancing Regions Deteriorated the Immunotherapeutic Efficacy of HSPPC-96 Vaccination in Treating Glioblastoma
por: Chi, Xiaohan, et al.
Publicado: (2022)

Prognostic role of extracellular matrix metalloproteinase inducer/CD147 in gastrointestinal cancer: a meta-analysis of related studies
por: Huang, Xiaohui, et al.
Publicado: (2016)

Long noncoding RNA AOC4P regulates tumor cell proliferation and invasion by epithelial–mesenchymal transition in gastric cancer
por: Zhang, Kecheng, et al.
Publicado: (2019)

Lymph Node Yield Following Packet Submission After Isolation By Surgeon During Gastrectomy
por: Wang, Pengpeng, et al.
Publicado: (2019)

Human α1-Antitrypsin Binds to Heat-Shock Protein gp96 and Protects from Endogenous gp96-Mediated Injury In vivo
por: Ochayon, David E., et al.
Publicado: (2013)

MiR-144-3p inhibits gastric cancer progression and stemness via directly targeting GLI2 involved in hedgehog pathway
por: Lu, Yixun, et al.
Publicado: (2021)

Low MxA Expression Predicts Better Immunotherapeutic Outcomes in Glioblastoma Patients Receiving Heat Shock Protein Peptide Complex 96 Vaccination
por: Wang, Yi, et al.
Publicado: (2022)

Serum HER2 Is a Potential Surrogate for Tissue HER2 Status in Gastric Cancer: A Systematic Review and Meta-Analysis
por: Zhang, Kecheng, et al.
Publicado: (2015)

Effect of preoperative nutrition therapy type and duration on short-time outcomes in gastric cancer patient with gastric outlet obstruction
por: Li, Jiyang, et al.
Publicado: (2021)

Shikonin induces ROS-based mitochondria-mediated apoptosis in colon cancer
por: Liang, Wenquan, et al.
Publicado: (2017)

Circulating Exosomal Gastric Cancer–Associated Long Noncoding RNA1 as a Biomarker for Early Detection and Monitoring Progression of Gastric Cancer: A Multiphase Study
por: Guo, Xin, et al.
Publicado: (2020)

Induction of Regulatory T Cells by High-Dose gp96 Suppresses Murine Liver Immune Hyperactivation
por: Li, Xinghui, et al.
Publicado: (2013)

Regulation of the Expression of Chaperone gp96 in Macrophages and Dendritic Cells
por: Wolfram, Lutz, et al.
Publicado: (2013)

Placenta-derived gp96 as a multivalent prophylactic cancer vaccine
por: Zhao, Bao, et al.
Publicado: (2013)

Gastric cancer-derived heat shock protein-gp96 peptide complex enhances dendritic cell activation
por: Lu, Wen-Wen, et al.
Publicado: (2017)

Surgical starting time of the day and survival in gastric cancer
por: Gao, Yunhe, et al.
Publicado: (2023)

MiR-378a-3p acts as a tumor suppressor in gastric cancer via directly targeting RAB31 and inhibiting the Hedgehog pathway proteins GLI1/2
por: Xu, Xinxin, et al.
Publicado: (2022)

Chaperone gp96 mediates ER-α36 cell membrane expression
por: Hou, Junwei, et al.
Publicado: (2015)

Plasma gp96 is a Novel Predictive Biomarker for Severe COVID-19
por: Wei, Rongguo, et al.
Publicado: (2021)

gp96 Expression in Gliomas and Its Association with Tumor Malignancy and T Cell Infiltrating Level
por: Li, Chunzhao, et al.
Publicado: (2022)

Dendritic cells pulsed with placental gp96 promote tumor-reactive immune responses
por: Zheng, Huaguo, et al.
Publicado: (2019)

Induction of Foxp3 and activation of Tregs by HSP gp96 for treatment of autoimmune diseases
por: Xu, Yuxiu, et al.
Publicado: (2021)

The Dual Nature of Specific Immunological Activity of Tumor-derived gp96 Preparations
por: Chandawarkar, Rajiv Y., et al.
Publicado: (1999)

Identification of gp96 as a Novel Target for Treatment of Autoimmune Disease in Mice
por: Han, Jung Min, et al.
Publicado: (2010)

Cell entry of a host-targeting protein of oomycetes requires gp96
por: Trusch, Franziska, et al.
Publicado: (2018)

Molecular Chaperone GRP94/GP96 in Cancers: Oncogenesis and Therapeutic Target
por: Duan, Xiaofeng, et al.
Publicado: (2021)

Autologous tumor-derived heat-shock protein peptide complex-96 (HSPPC-96) in patients with metastatic melanoma
por: Eton, Omar, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_aklauidbcsc9ts8enlgi5ni6is