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Cooperative binding mitigates the high-dose hook effect
BACKGROUND: The high-dose hook effect (also called prozone effect) refers to the observation that if a multivalent protein acts as a linker between two parts of a protein complex, then increasing the amount of linker protein in the mixture does not always increase the amount of fully formed complex....
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556679/ https://www.ncbi.nlm.nih.gov/pubmed/28807050 http://dx.doi.org/10.1186/s12918-017-0447-8 |