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Vaginal cuff brachytherapy in endometrial cancer – a technically easy treatment?

Endometrial cancer (EC) is one of the most common gynecological cancers among women in the developed countries. Vaginal cuff is the main location of relapses after a curative surgical procedure and postoperative radiation therapy have proven to diminish it. Nevertheless, these results have not trans...

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Autores principales: Sabater, Sebastià, Andres, Ignacio, Lopez-Honrubia, Veronica, Berenguer, Roberto, Sevillano, Marimar, Jimenez-Jimenez, Esther, Rovirosa, Angeles, Arenas, Meritxell
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557121/
https://www.ncbi.nlm.nih.gov/pubmed/28848362
http://dx.doi.org/10.2147/CMAR.S119125
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author Sabater, Sebastià
Andres, Ignacio
Lopez-Honrubia, Veronica
Berenguer, Roberto
Sevillano, Marimar
Jimenez-Jimenez, Esther
Rovirosa, Angeles
Arenas, Meritxell
author_facet Sabater, Sebastià
Andres, Ignacio
Lopez-Honrubia, Veronica
Berenguer, Roberto
Sevillano, Marimar
Jimenez-Jimenez, Esther
Rovirosa, Angeles
Arenas, Meritxell
author_sort Sabater, Sebastià
collection PubMed
description Endometrial cancer (EC) is one of the most common gynecological cancers among women in the developed countries. Vaginal cuff is the main location of relapses after a curative surgical procedure and postoperative radiation therapy have proven to diminish it. Nevertheless, these results have not translated into better survival results. The preeminent place of vaginal cuff brachytherapy (VCB) in the postoperative treatment of high- to intermediate-risk EC was given by the PORTEC-2 trial, which demonstrated a similar reduction in relapses with VCB than with external beam radiotherapy (EBRT), but VCB induced less late toxicity. As a result of this trial, the use of VCB has increased in clinical practice at the expense of EBRT. A majority of the clinical reviews of VCB usually address the risk categories and patient selection but pay little attention to technical aspects of the VCB procedure. Our review aimed to address both aspects. First of all, we described the risk groups, which guide patient selection for VCB in clinical practice. Then, we depicted several technical aspects that might influence dose deposition and toxicity. Bladder distension and rectal distension as well as applicator position or patient position are some of those variables that we reviewed.
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spelling pubmed-55571212017-08-28 Vaginal cuff brachytherapy in endometrial cancer – a technically easy treatment? Sabater, Sebastià Andres, Ignacio Lopez-Honrubia, Veronica Berenguer, Roberto Sevillano, Marimar Jimenez-Jimenez, Esther Rovirosa, Angeles Arenas, Meritxell Cancer Manag Res Review Endometrial cancer (EC) is one of the most common gynecological cancers among women in the developed countries. Vaginal cuff is the main location of relapses after a curative surgical procedure and postoperative radiation therapy have proven to diminish it. Nevertheless, these results have not translated into better survival results. The preeminent place of vaginal cuff brachytherapy (VCB) in the postoperative treatment of high- to intermediate-risk EC was given by the PORTEC-2 trial, which demonstrated a similar reduction in relapses with VCB than with external beam radiotherapy (EBRT), but VCB induced less late toxicity. As a result of this trial, the use of VCB has increased in clinical practice at the expense of EBRT. A majority of the clinical reviews of VCB usually address the risk categories and patient selection but pay little attention to technical aspects of the VCB procedure. Our review aimed to address both aspects. First of all, we described the risk groups, which guide patient selection for VCB in clinical practice. Then, we depicted several technical aspects that might influence dose deposition and toxicity. Bladder distension and rectal distension as well as applicator position or patient position are some of those variables that we reviewed. Dove Medical Press 2017-08-09 /pmc/articles/PMC5557121/ /pubmed/28848362 http://dx.doi.org/10.2147/CMAR.S119125 Text en © 2017 Sabater et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Sabater, Sebastià
Andres, Ignacio
Lopez-Honrubia, Veronica
Berenguer, Roberto
Sevillano, Marimar
Jimenez-Jimenez, Esther
Rovirosa, Angeles
Arenas, Meritxell
Vaginal cuff brachytherapy in endometrial cancer – a technically easy treatment?
title Vaginal cuff brachytherapy in endometrial cancer – a technically easy treatment?
title_full Vaginal cuff brachytherapy in endometrial cancer – a technically easy treatment?
title_fullStr Vaginal cuff brachytherapy in endometrial cancer – a technically easy treatment?
title_full_unstemmed Vaginal cuff brachytherapy in endometrial cancer – a technically easy treatment?
title_short Vaginal cuff brachytherapy in endometrial cancer – a technically easy treatment?
title_sort vaginal cuff brachytherapy in endometrial cancer – a technically easy treatment?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557121/
https://www.ncbi.nlm.nih.gov/pubmed/28848362
http://dx.doi.org/10.2147/CMAR.S119125
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