Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions

Identification of effective combination therapies is critical to address the emergence of drug-resistant cancers, but direct screening of all possible drug combinations is infeasible. Here we introduce a CRISPR-based double knockout (CDKO) system that improves the efficiency of combinatorial genetic...

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Detalles Bibliográficos
Autores principales: Han, Kyuho, Jeng, Edwin E., Hess, Gaelen T., Morgens, David W., Li, Amy, Bassik, Michael C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557292/
https://www.ncbi.nlm.nih.gov/pubmed/28319085
http://dx.doi.org/10.1038/nbt.3834

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557292/
https://www.ncbi.nlm.nih.gov/pubmed/28319085
http://dx.doi.org/10.1038/nbt.3834

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