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Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions

Identification of effective combination therapies is critical to address the emergence of drug-resistant cancers, but direct screening of all possible drug combinations is infeasible. Here we introduce a CRISPR-based double knockout (CDKO) system that improves the efficiency of combinatorial genetic...

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Detalles Bibliográficos
Autores principales:	Han, Kyuho, Jeng, Edwin E., Hess, Gaelen T., Morgens, David W., Li, Amy, Bassik, Michael C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557292/ https://www.ncbi.nlm.nih.gov/pubmed/28319085 http://dx.doi.org/10.1038/nbt.3834

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