Agonist anti-GITR antibody significantly enhances the therapeutic efficacy of Listeria monocytogenes-based immunotherapy

BACKGROUND: We previously demonstrated that in addition to generating an antigen-specific immune response, Listeria monocytogenes (Lm)-based immunotherapy significantly reduces the ratio of regulatory T cells (Tregs)/CD4(+) and myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment....

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Detalles Bibliográficos
Autores principales: Shrimali, Rajeev, Ahmad, Shamim, Berrong, Zuzana, Okoev, Grigori, Matevosyan, Adelaida, Razavi, Ghazaleh Shoja E., Petit, Robert, Gupta, Seema, Mkrtichyan, Mikayel, Khleif, Samir N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557467/
https://www.ncbi.nlm.nih.gov/pubmed/28807056
http://dx.doi.org/10.1186/s40425-017-0266-x

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