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Oncofertility in patients with stage I epithelial ovarian cancer: fertility-sparing surgery in young women of reproductive age
BACKGROUND: Fertility-sparing surgery is indicated for patients with stage I epithelial ovarian cancers. We sought to evaluate the clinical outcomes and oncofertility in a cohort of patients of reproductive age with stage I epithelial ovarian cancer (EOC). METHODS: Overall, 108 patients of reproduct...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557507/ https://www.ncbi.nlm.nih.gov/pubmed/28806962 http://dx.doi.org/10.1186/s12957-017-1222-4 |
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author | Jiang, Xuan Yang, Jiaxin Yu, Mei Xie, Weimin Cao, Dongyan Wu, Ming Pan, Lingya Huang, Huifang You, Yan Shen, Keng |
author_facet | Jiang, Xuan Yang, Jiaxin Yu, Mei Xie, Weimin Cao, Dongyan Wu, Ming Pan, Lingya Huang, Huifang You, Yan Shen, Keng |
author_sort | Jiang, Xuan |
collection | PubMed |
description | BACKGROUND: Fertility-sparing surgery is indicated for patients with stage I epithelial ovarian cancers. We sought to evaluate the clinical outcomes and oncofertility in a cohort of patients of reproductive age with stage I epithelial ovarian cancer (EOC). METHODS: Overall, 108 patients of reproductive age (≤ 40 years) diagnosed with stage I EOC who were treated at Peking Union Medical College Hospital between 1999 and 2013 were included in the study. The Kaplan-Meier model and Cox regression analyses were used for the survival analysis. RESULTS: The type of surgery included fertility-sparing surgery (FSS) (48.1%) and radical surgery (RS) (51.9%). After a median follow-up of 83 months, we observed that grade 3 or clear-cell carcinoma was the only independent risk factor for disease-free survival and tumor-specific survival in the multivariate analysis. Patients with grade 3 or clear-cell carcinoma tended to be older than 30 years, have endometriosis, and undergo RS (p < 0.05). Fertility-sparing surgery did not affect disease-free survival or tumor-specific survival among patients of reproductive age with stage I EOC and among high-risk patients with stage IC2-3, grade 3, or clear-cell carcinoma. Thirty-four out of 52 (65.4%) FSS patients attempted to get pregnant. Twenty-eight (82.4%) achieved a successful pregnancy with a full-term delivery. CONCLUSIONS: Grade 3 or clear-cell carcinoma was the only independent risk factor for survival of patients of reproductive age with stage I EOC. FSS can be safely performed on patients of reproductive age with grade 1-2, stage I EOC. The safety of FSS for grade 3 and clear-cell carcinoma warrants further investigation. |
format | Online Article Text |
id | pubmed-5557507 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-55575072017-08-18 Oncofertility in patients with stage I epithelial ovarian cancer: fertility-sparing surgery in young women of reproductive age Jiang, Xuan Yang, Jiaxin Yu, Mei Xie, Weimin Cao, Dongyan Wu, Ming Pan, Lingya Huang, Huifang You, Yan Shen, Keng World J Surg Oncol Research BACKGROUND: Fertility-sparing surgery is indicated for patients with stage I epithelial ovarian cancers. We sought to evaluate the clinical outcomes and oncofertility in a cohort of patients of reproductive age with stage I epithelial ovarian cancer (EOC). METHODS: Overall, 108 patients of reproductive age (≤ 40 years) diagnosed with stage I EOC who were treated at Peking Union Medical College Hospital between 1999 and 2013 were included in the study. The Kaplan-Meier model and Cox regression analyses were used for the survival analysis. RESULTS: The type of surgery included fertility-sparing surgery (FSS) (48.1%) and radical surgery (RS) (51.9%). After a median follow-up of 83 months, we observed that grade 3 or clear-cell carcinoma was the only independent risk factor for disease-free survival and tumor-specific survival in the multivariate analysis. Patients with grade 3 or clear-cell carcinoma tended to be older than 30 years, have endometriosis, and undergo RS (p < 0.05). Fertility-sparing surgery did not affect disease-free survival or tumor-specific survival among patients of reproductive age with stage I EOC and among high-risk patients with stage IC2-3, grade 3, or clear-cell carcinoma. Thirty-four out of 52 (65.4%) FSS patients attempted to get pregnant. Twenty-eight (82.4%) achieved a successful pregnancy with a full-term delivery. CONCLUSIONS: Grade 3 or clear-cell carcinoma was the only independent risk factor for survival of patients of reproductive age with stage I EOC. FSS can be safely performed on patients of reproductive age with grade 1-2, stage I EOC. The safety of FSS for grade 3 and clear-cell carcinoma warrants further investigation. BioMed Central 2017-08-15 /pmc/articles/PMC5557507/ /pubmed/28806962 http://dx.doi.org/10.1186/s12957-017-1222-4 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Jiang, Xuan Yang, Jiaxin Yu, Mei Xie, Weimin Cao, Dongyan Wu, Ming Pan, Lingya Huang, Huifang You, Yan Shen, Keng Oncofertility in patients with stage I epithelial ovarian cancer: fertility-sparing surgery in young women of reproductive age |
title | Oncofertility in patients with stage I epithelial ovarian cancer: fertility-sparing surgery in young women of reproductive age |
title_full | Oncofertility in patients with stage I epithelial ovarian cancer: fertility-sparing surgery in young women of reproductive age |
title_fullStr | Oncofertility in patients with stage I epithelial ovarian cancer: fertility-sparing surgery in young women of reproductive age |
title_full_unstemmed | Oncofertility in patients with stage I epithelial ovarian cancer: fertility-sparing surgery in young women of reproductive age |
title_short | Oncofertility in patients with stage I epithelial ovarian cancer: fertility-sparing surgery in young women of reproductive age |
title_sort | oncofertility in patients with stage i epithelial ovarian cancer: fertility-sparing surgery in young women of reproductive age |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557507/ https://www.ncbi.nlm.nih.gov/pubmed/28806962 http://dx.doi.org/10.1186/s12957-017-1222-4 |
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