Quantification of mutant SPOP proteins in prostate cancer using mass spectrometry-based targeted proteomics

BACKGROUND: Speckle-type POZ protein (SPOP) is an E3 ubiquitin ligase adaptor protein that functions as a potential tumor suppressor, and SPOP mutations have been identified in ~10% of human prostate cancers. However, it remains unclear if mutant SPOP proteins can be utilized as biomarkers for early...

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Detalles Bibliográficos
Autores principales: Wang, Hui, Barbieri, Christopher E., He, Jintang, Gao, Yuqian, Shi, Tujin, Wu, Chaochao, Schepmoes, Athena A., Fillmore, Thomas L., Chae, Sung-Suk, Huang, Dennis, Mosquera, Juan Miguel, Qian, Wei-Jun, Smith, Richard D., Srivastava, Sudhir, Kagan, Jacob, Camp, David G., Rodland, Karin D., Rubin, Mark A., Liu, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557563/
https://www.ncbi.nlm.nih.gov/pubmed/28810879
http://dx.doi.org/10.1186/s12967-017-1276-7

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