Metabolomic profiling of amines in sepsis predicts changes in NOS canonical pathways

RATIONALE: Nitric oxide synthase (NOS) is a biomarker/target in sepsis. NOS activity is driven by amino acids, which cycle to regulate the substrate L-arginine in parallel with cycles which regulate the endogenous inhibitors ADMA and L-NMMA. The relationship between amines and the consequence of pla...

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Detalles Bibliográficos
Autores principales: Tesfai, Abel, MacCallum, Niall, Kirkby, Nicholas S., Gashaw, Hime, Gray, Nicola, Want, Elizabeth, Quinlan, Gregory J., Mumby, Sharon, Leiper, James M., Paul-Clark, Mark, Ahmetaj-Shala, Blerina, Mitchell, Jane A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557592/
https://www.ncbi.nlm.nih.gov/pubmed/28813479
http://dx.doi.org/10.1371/journal.pone.0183025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557592/
https://www.ncbi.nlm.nih.gov/pubmed/28813479
http://dx.doi.org/10.1371/journal.pone.0183025

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