Brain micro-inflammation at specific vessels dysregulates organ-homeostasis via the activation of a new neural circuit

Impact of stress on diseases including gastrointestinal failure is well-known, but molecular mechanism is not understood. Here we show underlying molecular mechanism using EAE mice. Under stress conditions, EAE caused severe gastrointestinal failure with high-mortality. Mechanistically, autoreactive...

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Detalles Bibliográficos
Autores principales: Arima, Yasunobu, Ohki, Takuto, Nishikawa, Naoki, Higuchi, Kotaro, Ota, Mitsutoshi, Tanaka, Yuki, Nio-Kobayashi, Junko, Elfeky, Mohamed, Sakai, Ryota, Mori, Yuki, Kawamoto, Tadafumi, Stofkova, Andrea, Sakashita, Yukihiro, Morimoto, Yuji, Kuwatani, Masaki, Iwanaga, Toshihiko, Yoshioka, Yoshichika, Sakamoto, Naoya, Yoshimura, Akihiko, Takiguchi, Mitsuyoshi, Sakoda, Saburo, Prinz, Marco, Kamimura, Daisuke, Murakami, Masaaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557598/
https://www.ncbi.nlm.nih.gov/pubmed/28809157
http://dx.doi.org/10.7554/eLife.25517

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557598/
https://www.ncbi.nlm.nih.gov/pubmed/28809157
http://dx.doi.org/10.7554/eLife.25517

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