Transcription factor ZNF148 is a negative regulator of human muscle differentiation

Muscle differentiation is a complex process in which muscle progenitor cells undergo determination and eventually cellular fusion. This process is heavily regulated by such master transcription factors as MYOD and members of the MEF2 family. Here, we show that the transcription factor ZNF148 plays a...

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Detalles Bibliográficos
Autores principales: Bakke, Jesse, Wright, William C., Zamora, Anthony E., Ong, Su Sien, Wang, Yue-Ming, Hoyer, Jessica D., Brewer, Christopher T., Thomas, Paul G., Chen, Taosheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557752/
https://www.ncbi.nlm.nih.gov/pubmed/28811660
http://dx.doi.org/10.1038/s41598-017-08267-5
Descripción
Sumario:Muscle differentiation is a complex process in which muscle progenitor cells undergo determination and eventually cellular fusion. This process is heavily regulated by such master transcription factors as MYOD and members of the MEF2 family. Here, we show that the transcription factor ZNF148 plays a direct role in human muscle cell differentiation. Downregulation of ZNF148 drives the formation of a muscle phenotype with rapid expression of myosin heavy chain, even in proliferative conditions. This phenotype was most likely mediated by the robust and swift upregulation of MYOD and MEF2C.

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