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Transcription factor ZNF148 is a negative regulator of human muscle differentiation

Muscle differentiation is a complex process in which muscle progenitor cells undergo determination and eventually cellular fusion. This process is heavily regulated by such master transcription factors as MYOD and members of the MEF2 family. Here, we show that the transcription factor ZNF148 plays a...

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Autores principales: Bakke, Jesse, Wright, William C., Zamora, Anthony E., Ong, Su Sien, Wang, Yue-Ming, Hoyer, Jessica D., Brewer, Christopher T., Thomas, Paul G., Chen, Taosheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557752/
https://www.ncbi.nlm.nih.gov/pubmed/28811660
http://dx.doi.org/10.1038/s41598-017-08267-5
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author Bakke, Jesse
Wright, William C.
Zamora, Anthony E.
Ong, Su Sien
Wang, Yue-Ming
Hoyer, Jessica D.
Brewer, Christopher T.
Thomas, Paul G.
Chen, Taosheng
author_facet Bakke, Jesse
Wright, William C.
Zamora, Anthony E.
Ong, Su Sien
Wang, Yue-Ming
Hoyer, Jessica D.
Brewer, Christopher T.
Thomas, Paul G.
Chen, Taosheng
author_sort Bakke, Jesse
collection PubMed
description Muscle differentiation is a complex process in which muscle progenitor cells undergo determination and eventually cellular fusion. This process is heavily regulated by such master transcription factors as MYOD and members of the MEF2 family. Here, we show that the transcription factor ZNF148 plays a direct role in human muscle cell differentiation. Downregulation of ZNF148 drives the formation of a muscle phenotype with rapid expression of myosin heavy chain, even in proliferative conditions. This phenotype was most likely mediated by the robust and swift upregulation of MYOD and MEF2C.
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spelling pubmed-55577522017-08-16 Transcription factor ZNF148 is a negative regulator of human muscle differentiation Bakke, Jesse Wright, William C. Zamora, Anthony E. Ong, Su Sien Wang, Yue-Ming Hoyer, Jessica D. Brewer, Christopher T. Thomas, Paul G. Chen, Taosheng Sci Rep Article Muscle differentiation is a complex process in which muscle progenitor cells undergo determination and eventually cellular fusion. This process is heavily regulated by such master transcription factors as MYOD and members of the MEF2 family. Here, we show that the transcription factor ZNF148 plays a direct role in human muscle cell differentiation. Downregulation of ZNF148 drives the formation of a muscle phenotype with rapid expression of myosin heavy chain, even in proliferative conditions. This phenotype was most likely mediated by the robust and swift upregulation of MYOD and MEF2C. Nature Publishing Group UK 2017-08-15 /pmc/articles/PMC5557752/ /pubmed/28811660 http://dx.doi.org/10.1038/s41598-017-08267-5 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Bakke, Jesse
Wright, William C.
Zamora, Anthony E.
Ong, Su Sien
Wang, Yue-Ming
Hoyer, Jessica D.
Brewer, Christopher T.
Thomas, Paul G.
Chen, Taosheng
Transcription factor ZNF148 is a negative regulator of human muscle differentiation
title Transcription factor ZNF148 is a negative regulator of human muscle differentiation
title_full Transcription factor ZNF148 is a negative regulator of human muscle differentiation
title_fullStr Transcription factor ZNF148 is a negative regulator of human muscle differentiation
title_full_unstemmed Transcription factor ZNF148 is a negative regulator of human muscle differentiation
title_short Transcription factor ZNF148 is a negative regulator of human muscle differentiation
title_sort transcription factor znf148 is a negative regulator of human muscle differentiation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557752/
https://www.ncbi.nlm.nih.gov/pubmed/28811660
http://dx.doi.org/10.1038/s41598-017-08267-5
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