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Transcription factor ZNF148 is a negative regulator of human muscle differentiation
Muscle differentiation is a complex process in which muscle progenitor cells undergo determination and eventually cellular fusion. This process is heavily regulated by such master transcription factors as MYOD and members of the MEF2 family. Here, we show that the transcription factor ZNF148 plays a...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557752/ https://www.ncbi.nlm.nih.gov/pubmed/28811660 http://dx.doi.org/10.1038/s41598-017-08267-5 |
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author | Bakke, Jesse Wright, William C. Zamora, Anthony E. Ong, Su Sien Wang, Yue-Ming Hoyer, Jessica D. Brewer, Christopher T. Thomas, Paul G. Chen, Taosheng |
author_facet | Bakke, Jesse Wright, William C. Zamora, Anthony E. Ong, Su Sien Wang, Yue-Ming Hoyer, Jessica D. Brewer, Christopher T. Thomas, Paul G. Chen, Taosheng |
author_sort | Bakke, Jesse |
collection | PubMed |
description | Muscle differentiation is a complex process in which muscle progenitor cells undergo determination and eventually cellular fusion. This process is heavily regulated by such master transcription factors as MYOD and members of the MEF2 family. Here, we show that the transcription factor ZNF148 plays a direct role in human muscle cell differentiation. Downregulation of ZNF148 drives the formation of a muscle phenotype with rapid expression of myosin heavy chain, even in proliferative conditions. This phenotype was most likely mediated by the robust and swift upregulation of MYOD and MEF2C. |
format | Online Article Text |
id | pubmed-5557752 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-55577522017-08-16 Transcription factor ZNF148 is a negative regulator of human muscle differentiation Bakke, Jesse Wright, William C. Zamora, Anthony E. Ong, Su Sien Wang, Yue-Ming Hoyer, Jessica D. Brewer, Christopher T. Thomas, Paul G. Chen, Taosheng Sci Rep Article Muscle differentiation is a complex process in which muscle progenitor cells undergo determination and eventually cellular fusion. This process is heavily regulated by such master transcription factors as MYOD and members of the MEF2 family. Here, we show that the transcription factor ZNF148 plays a direct role in human muscle cell differentiation. Downregulation of ZNF148 drives the formation of a muscle phenotype with rapid expression of myosin heavy chain, even in proliferative conditions. This phenotype was most likely mediated by the robust and swift upregulation of MYOD and MEF2C. Nature Publishing Group UK 2017-08-15 /pmc/articles/PMC5557752/ /pubmed/28811660 http://dx.doi.org/10.1038/s41598-017-08267-5 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Bakke, Jesse Wright, William C. Zamora, Anthony E. Ong, Su Sien Wang, Yue-Ming Hoyer, Jessica D. Brewer, Christopher T. Thomas, Paul G. Chen, Taosheng Transcription factor ZNF148 is a negative regulator of human muscle differentiation |
title | Transcription factor ZNF148 is a negative regulator of human muscle differentiation |
title_full | Transcription factor ZNF148 is a negative regulator of human muscle differentiation |
title_fullStr | Transcription factor ZNF148 is a negative regulator of human muscle differentiation |
title_full_unstemmed | Transcription factor ZNF148 is a negative regulator of human muscle differentiation |
title_short | Transcription factor ZNF148 is a negative regulator of human muscle differentiation |
title_sort | transcription factor znf148 is a negative regulator of human muscle differentiation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557752/ https://www.ncbi.nlm.nih.gov/pubmed/28811660 http://dx.doi.org/10.1038/s41598-017-08267-5 |
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