Alteration of sheep coat color pattern by disruption of ASIP gene via CRISPR Cas9

Coat color is an important characteristic and economic trait in domestic sheep. Aiming at alteration of Chinese merino sheep coat color by genome manipulation, we disrupted sheep agouti signaling protein gene by CRISPR/Cas9. A total of seven indels were identified in 5 of 6 born lambs. Each targeted...

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Detalles Bibliográficos
Autores principales: Zhang, Xuemei, Li, Wenrong, Liu, Chenxi, Peng, Xinrong, Lin, Jiapeng, He, Sangang, Li, Xuejiao, Han, Bing, Zhang, Ning, Wu, Yangsheng, Chen, Lei, Wang, Liqin, MaYila, Huang, Juncheng, Liu, Mingjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557758/
https://www.ncbi.nlm.nih.gov/pubmed/28811591
http://dx.doi.org/10.1038/s41598-017-08636-0

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