Inhibition of connexin hemichannels alleviates non-alcoholic steatohepatitis in mice

While gap junctions mediate intercellular communication and support liver homeostasis, connexin hemichannels are preferentially opened by pathological stimuli, including inflammation and oxidative stress. The latter are essential features of non-alcoholic steatohepatitis. In this study, it was inves...

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Detalles Bibliográficos
Autores principales: Willebrords, Joost, Cogliati, Bruno, Pereira, Isabel Veloso Alves, da Silva, Tereza Cristina, Crespo Yanguas, Sara, Maes, Michaël, Govoni, Veronica Mollica, Lima, Andressa, Felisbino, Daniele Aparecida, Decrock, Elke, Nogueira, Marina Sayuri, de Castro, Inar Alves, Leclercq, Isabelle, Leybaert, Luc, Rodrigues, Robim Marcelino, Vinken, Mathieu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557827/
https://www.ncbi.nlm.nih.gov/pubmed/28811572
http://dx.doi.org/10.1038/s41598-017-08583-w

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