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Improving a genetically encoded voltage indicator by modifying the cytoplasmic charge composition

An improved genetically encoded voltage indicator (GEVI) was achieved by altering the charge composition of the region linking the voltage-sensing domain of the GEVI to a pH-sensitive fluorescent protein. Negatively charged linker segments reduced the voltage-dependent optical signal while positivel...

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Detalles Bibliográficos
Autores principales:	Lee, Sungmoo, Geiller, Tristan, Jung, Arong, Nakajima, Ryuichi, Song, Yoon-Kyu, Baker, Bradley J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557843/ https://www.ncbi.nlm.nih.gov/pubmed/28811673 http://dx.doi.org/10.1038/s41598-017-08731-2

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