2,4,6-Trinitrotoluene Induces Apoptosis via ROS-Regulated Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in HepG2 and Hep3B Cells

2,4,6-trinitrotoluene (TNT) has been reported to cause numerous adverse effects. However, the detailed molecular mechanisms underlying TNT-induced liver toxicity need to be elucidated. In this study, we used HepG2 (p53wt) and Hep3B (p53null) cell lines to investigate the cytotoxic effects of TNT. At...

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Detalles Bibliográficos
Autores principales: Liao, Hung-Yu, Kao, Chih-Ming, Yao, Chao-Ling, Chiu, Po-Wei, Yao, Chun-Chen, Chen, Ssu-Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557873/
https://www.ncbi.nlm.nih.gov/pubmed/28811603
http://dx.doi.org/10.1038/s41598-017-08308-z

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