Multimerization is required for antigen binding activity of an engineered IgM/IgG chimeric antibody recognizing a skin-related antigen

Monoclonal antibodies offer great tools for research. We encountered a potentially useful mouse IgM monoclonal antibody whose antigen is expressed in normal skin but lost in human skin cancer. Because IgM is difficult to work with and the antigen was unknown, we decided to convert the IgM (µ) to IgG...

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Detalles Bibliográficos
Autores principales: Teye, Kwesi, Hashimoto, Koji, Numata, Sanae, Ohta, Kunihiro, Haftek, Marek, Hashimoto, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557880/
https://www.ncbi.nlm.nih.gov/pubmed/28811604
http://dx.doi.org/10.1038/s41598-017-08294-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557880/
https://www.ncbi.nlm.nih.gov/pubmed/28811604
http://dx.doi.org/10.1038/s41598-017-08294-2

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