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Biogenesis of Pro-senescent Microparticles by Endothelial Colony Forming Cells from Premature Neonates is driven by SIRT1-Dependent Epigenetic Regulation of MKK6

Senescent cells may exert detrimental effect on microenvironment through the secretion of soluble factors and the release of extracellular vesicles, such as microparticles, key actors in ageing and cardiovascular diseases. We previously reported that sirtuin-1 (SIRT1) deficiency drives accelerated s...

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Detalles Bibliográficos
Autores principales:	Simoncini, Stéphanie, Chateau, Anne-Line, Robert, Stéphane, Todorova, Dilyana, Yzydorzick, Catherine, Lacroix, Romaric, Ligi, Isabelle, Louis, Laurence, Bachelier, Richard, Simeoni, Umberto, Magdinier, Frédérique, Dignat-George, Françoise, Sabatier, Florence
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557933/ https://www.ncbi.nlm.nih.gov/pubmed/28811647 http://dx.doi.org/10.1038/s41598-017-08883-1

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