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Characterisation of sterol biosynthesis and validation of 14α-demethylase as a drug target in Acanthamoeba

The soil amoebae Acanthamoeba causes Acanthamoeba keratitis, a severe sight-threatening infection of the eye and the almost universally fatal granulomatous amoebic encephalitis. More effective treatments are required. Sterol biosynthesis has been effectively targeted in numerous fungi using azole co...

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Detalles Bibliográficos
Autores principales:	Thomson, Scott, Rice, Christopher A., Zhang, Tong, Edrada-Ebel, RuAngelie, Henriquez, Fiona L., Roberts, Craig W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557935/ https://www.ncbi.nlm.nih.gov/pubmed/28811501 http://dx.doi.org/10.1038/s41598-017-07495-z

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