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Outbreak and genotyping of canine distemper virus in captive Siberian tigers and red pandas

In this study, four canine distemper virus (CDV) strains were isolated from captive Siberian tigers (Panthera tigris altaica) and red pandas (Ailurus fulgens) during two separate CDV outbreaks in a zoo in Guangdong province, China. Sequence alignment and phylogenetic analyses based on the full-lengt...

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Autores principales: Zhang, He, Shan, Fen, Zhou, Xia, Li, Bing, Zhai, Jun-Qiong, Zou, Shu-Zhan, Wu, Meng-Fan, Chen, Wu, Zhai, Shao-Lun, Luo, Man-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557937/
https://www.ncbi.nlm.nih.gov/pubmed/28811626
http://dx.doi.org/10.1038/s41598-017-08462-4
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author Zhang, He
Shan, Fen
Zhou, Xia
Li, Bing
Zhai, Jun-Qiong
Zou, Shu-Zhan
Wu, Meng-Fan
Chen, Wu
Zhai, Shao-Lun
Luo, Man-Lin
author_facet Zhang, He
Shan, Fen
Zhou, Xia
Li, Bing
Zhai, Jun-Qiong
Zou, Shu-Zhan
Wu, Meng-Fan
Chen, Wu
Zhai, Shao-Lun
Luo, Man-Lin
author_sort Zhang, He
collection PubMed
description In this study, four canine distemper virus (CDV) strains were isolated from captive Siberian tigers (Panthera tigris altaica) and red pandas (Ailurus fulgens) during two separate CDV outbreaks in a zoo in Guangdong province, China. Sequence alignment and phylogenetic analyses based on the full-length hemagglutinin (H) and fusion (F) genes showed that they were closely identical to genotype Asia-1. Prior to confirmation of CDV in Siberian tigers, to control spread of the disease, a live attenuated combination CDV vaccine was used among almost all carnivore animals except for red pandas in which another recombinant combination CDV vaccine was used. However, about two months later, CDV re-emerged and caused the death among red pandas. Based on the vaccination records, the live combination vaccine could be considered an ideal weapon against CDV in zoo carnivore animals. Although the recombinant combination CDV vaccine was safe for red pandas, its protection effectiveness remains to be further investigated. Moreover, according to the outbreak interval time and sequence characterization, we suspected that stray cats circulating in the zoo were the intermediate host, which contributed to CDV spread from stray dogs to zoo animals. This study revealed the importance of vaccination and biosecurity for zoo animals.
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spelling pubmed-55579372017-08-16 Outbreak and genotyping of canine distemper virus in captive Siberian tigers and red pandas Zhang, He Shan, Fen Zhou, Xia Li, Bing Zhai, Jun-Qiong Zou, Shu-Zhan Wu, Meng-Fan Chen, Wu Zhai, Shao-Lun Luo, Man-Lin Sci Rep Article In this study, four canine distemper virus (CDV) strains were isolated from captive Siberian tigers (Panthera tigris altaica) and red pandas (Ailurus fulgens) during two separate CDV outbreaks in a zoo in Guangdong province, China. Sequence alignment and phylogenetic analyses based on the full-length hemagglutinin (H) and fusion (F) genes showed that they were closely identical to genotype Asia-1. Prior to confirmation of CDV in Siberian tigers, to control spread of the disease, a live attenuated combination CDV vaccine was used among almost all carnivore animals except for red pandas in which another recombinant combination CDV vaccine was used. However, about two months later, CDV re-emerged and caused the death among red pandas. Based on the vaccination records, the live combination vaccine could be considered an ideal weapon against CDV in zoo carnivore animals. Although the recombinant combination CDV vaccine was safe for red pandas, its protection effectiveness remains to be further investigated. Moreover, according to the outbreak interval time and sequence characterization, we suspected that stray cats circulating in the zoo were the intermediate host, which contributed to CDV spread from stray dogs to zoo animals. This study revealed the importance of vaccination and biosecurity for zoo animals. Nature Publishing Group UK 2017-08-15 /pmc/articles/PMC5557937/ /pubmed/28811626 http://dx.doi.org/10.1038/s41598-017-08462-4 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Zhang, He
Shan, Fen
Zhou, Xia
Li, Bing
Zhai, Jun-Qiong
Zou, Shu-Zhan
Wu, Meng-Fan
Chen, Wu
Zhai, Shao-Lun
Luo, Man-Lin
Outbreak and genotyping of canine distemper virus in captive Siberian tigers and red pandas
title Outbreak and genotyping of canine distemper virus in captive Siberian tigers and red pandas
title_full Outbreak and genotyping of canine distemper virus in captive Siberian tigers and red pandas
title_fullStr Outbreak and genotyping of canine distemper virus in captive Siberian tigers and red pandas
title_full_unstemmed Outbreak and genotyping of canine distemper virus in captive Siberian tigers and red pandas
title_short Outbreak and genotyping of canine distemper virus in captive Siberian tigers and red pandas
title_sort outbreak and genotyping of canine distemper virus in captive siberian tigers and red pandas
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557937/
https://www.ncbi.nlm.nih.gov/pubmed/28811626
http://dx.doi.org/10.1038/s41598-017-08462-4
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