Up-regulation of NADPH oxidase-mediated redox signaling contributes to the loss of barrier function in KRIT1 deficient endothelium

The intracellular scaffold KRIT1/CCM1 is an established regulator of vascular barrier function. Loss of KRIT1 leads to decreased microvessel barrier function and to the development of the vascular disorder Cerebral Cavernous Malformation (CCM). However, how loss of KRIT1 causes the subsequent defici...

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Detalles Bibliográficos
Autores principales: Goitre, Luca, DiStefano, Peter V., Moglia, Andrea, Nobiletti, Nicholas, Baldini, Eva, Trabalzini, Lorenza, Keubel, Julie, Trapani, Eliana, Shuvaev, Vladimir V., Muzykantov, Vladimir R., Sarelius, Ingrid H., Retta, Saverio Francesco, Glading, Angela J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558000/
https://www.ncbi.nlm.nih.gov/pubmed/28811547
http://dx.doi.org/10.1038/s41598-017-08373-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558000/
https://www.ncbi.nlm.nih.gov/pubmed/28811547
http://dx.doi.org/10.1038/s41598-017-08373-4

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