Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles

Mutations in many centriolar protein-encoding genes cause primary microcephaly. Using super-resolution and electron microscopy, we find that the human microcephaly protein, RTTN, is recruited to the proximal end of the procentriole at early S phase, and is located at the inner luminal walls of centr...

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Detalles Bibliográficos
Autores principales: Chen, Hsin-Yi, Wu, Chien-Ting, Tang, Chieh-Ju C., Lin, Yi-Nan, Wang, Won-Jing, Tang, Tang K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558016/
https://www.ncbi.nlm.nih.gov/pubmed/28811500
http://dx.doi.org/10.1038/s41467-017-00305-0

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