Noncanonical GLI1 signaling promotes stemness features and in vivo growth in lung adenocarcinoma

Aberrant Hedgehog/GLI signaling has been implicated in a diverse spectrum of human cancers, but its role in lung adenocarcinoma (LAC) is still under debate. We show that the downstream effector of the Hedgehog pathway, GLI1, is expressed in 76% of LACs, but in roughly half of these tumors, the canon...

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Detalles Bibliográficos
Autores principales: Po, A, Silvano, M, Miele, E, Capalbo, C, Eramo, A, Salvati, V, Todaro, M, Besharat, Z M, Catanzaro, G, Cucchi, D, Coni, S, Di Marcotullio, L, Canettieri, G, Vacca, A, Stassi, G, De Smaele, E, Tartaglia, M, Screpanti, I, De Maria, R, Ferretti, E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558095/
https://www.ncbi.nlm.nih.gov/pubmed/28368412
http://dx.doi.org/10.1038/onc.2017.91

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