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Recent advances in understanding basophil functions in vivo

Basophils are mainly known as pro-inflammatory effector cells associated with allergy and helminth infections. Although they were identified over 130 years ago, their in vivo functions are still poorly understood. New insights into basophil development and function have been gained by the developmen...

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Autor principal: Voehringer, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558098/
https://www.ncbi.nlm.nih.gov/pubmed/28868143
http://dx.doi.org/10.12688/f1000research.11697.1
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author Voehringer, David
author_facet Voehringer, David
author_sort Voehringer, David
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description Basophils are mainly known as pro-inflammatory effector cells associated with allergy and helminth infections. Although they were identified over 130 years ago, their in vivo functions are still poorly understood. New insights into basophil development and function have been gained by the development of various transgenic mouse lines and staining techniques to detect and purify these cells from different organs. Several studies over the past few years have identified unexpected functions for basophils, including immunomodulatory properties and interactions with other immune cells. Here, I summarize and discuss the main findings.
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spelling pubmed-55580982017-08-31 Recent advances in understanding basophil functions in vivo Voehringer, David F1000Res Review Basophils are mainly known as pro-inflammatory effector cells associated with allergy and helminth infections. Although they were identified over 130 years ago, their in vivo functions are still poorly understood. New insights into basophil development and function have been gained by the development of various transgenic mouse lines and staining techniques to detect and purify these cells from different organs. Several studies over the past few years have identified unexpected functions for basophils, including immunomodulatory properties and interactions with other immune cells. Here, I summarize and discuss the main findings. F1000Research 2017-08-15 /pmc/articles/PMC5558098/ /pubmed/28868143 http://dx.doi.org/10.12688/f1000research.11697.1 Text en Copyright: © 2017 Voehringer D http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Voehringer, David
Recent advances in understanding basophil functions in vivo
title Recent advances in understanding basophil functions in vivo
title_full Recent advances in understanding basophil functions in vivo
title_fullStr Recent advances in understanding basophil functions in vivo
title_full_unstemmed Recent advances in understanding basophil functions in vivo
title_short Recent advances in understanding basophil functions in vivo
title_sort recent advances in understanding basophil functions in vivo
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558098/
https://www.ncbi.nlm.nih.gov/pubmed/28868143
http://dx.doi.org/10.12688/f1000research.11697.1
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