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Telmisartan decreases microalbuminuria in patients with type 2 diabetes mellitus following coronary artery bypass grafting

OBJECTIVE: This prospective study aimed to investigate the effects of the selective angiotensin receptor antagonist, telmisartan, on microalbuminuria after coronary artery bypass surgery in patients with diabetes mellitus. METHODS: Patients were divided into two groups with block randomisation, usin...

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Autores principales: Furat, Cevdet, Dogan, Riza, Ilhan, Gokhan, Bayar, Ekrem, Ozpak, Berkan, Kara, Hakan, Bozok, Şahin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Clinics Cardive Publishing 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558141/
https://www.ncbi.nlm.nih.gov/pubmed/27834982
http://dx.doi.org/10.5830/CVJA-2016-089
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author Furat, Cevdet
Dogan, Riza
Ilhan, Gokhan
Bayar, Ekrem
Ozpak, Berkan
Kara, Hakan
Bozok, Şahin
author_facet Furat, Cevdet
Dogan, Riza
Ilhan, Gokhan
Bayar, Ekrem
Ozpak, Berkan
Kara, Hakan
Bozok, Şahin
author_sort Furat, Cevdet
collection PubMed
description OBJECTIVE: This prospective study aimed to investigate the effects of the selective angiotensin receptor antagonist, telmisartan, on microalbuminuria after coronary artery bypass surgery in patients with diabetes mellitus. METHODS: Patients were divided into two groups with block randomisation, using the sealed envelope technique: group T (telmisartan group) consisted of patients who received the angiotensin receptor blocking agent telmisartan 80 mg daily for at least six months in the pre-operative period; group N-T (non-telmisartan group) consisted of patients who received no telmisartan treatment. Clinical and demographic characteristics, operative and postoperative features, microalbuminuria and high-sensitivity C-reactive protein levels were compared. RESULTS: Forty patients met the eligibility criteria for the study. The groups did not differ with regard to clinical and demographic characteristics, and operative and postoperative features. Microalbuminuria levels between the groups differed significantly in the pre-operative period, first hour postoperatively and fifth day postoperatively. C-reactive protein levels between the groups differed significantly on the fifth day postoperatively. CONCLUSION: Telmisartan was useful for decreasing systemic inflammation and levels of urinary albumin excretion in patients who had type 2 diabetes mellitus and had undergone coronary artery bypass surgery.
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spelling pubmed-55581412017-08-30 Telmisartan decreases microalbuminuria in patients with type 2 diabetes mellitus following coronary artery bypass grafting Furat, Cevdet Dogan, Riza Ilhan, Gokhan Bayar, Ekrem Ozpak, Berkan Kara, Hakan Bozok, Şahin Cardiovasc J Afr Cardiovascular Topics OBJECTIVE: This prospective study aimed to investigate the effects of the selective angiotensin receptor antagonist, telmisartan, on microalbuminuria after coronary artery bypass surgery in patients with diabetes mellitus. METHODS: Patients were divided into two groups with block randomisation, using the sealed envelope technique: group T (telmisartan group) consisted of patients who received the angiotensin receptor blocking agent telmisartan 80 mg daily for at least six months in the pre-operative period; group N-T (non-telmisartan group) consisted of patients who received no telmisartan treatment. Clinical and demographic characteristics, operative and postoperative features, microalbuminuria and high-sensitivity C-reactive protein levels were compared. RESULTS: Forty patients met the eligibility criteria for the study. The groups did not differ with regard to clinical and demographic characteristics, and operative and postoperative features. Microalbuminuria levels between the groups differed significantly in the pre-operative period, first hour postoperatively and fifth day postoperatively. C-reactive protein levels between the groups differed significantly on the fifth day postoperatively. CONCLUSION: Telmisartan was useful for decreasing systemic inflammation and levels of urinary albumin excretion in patients who had type 2 diabetes mellitus and had undergone coronary artery bypass surgery. Clinics Cardive Publishing 2017 /pmc/articles/PMC5558141/ /pubmed/27834982 http://dx.doi.org/10.5830/CVJA-2016-089 Text en Copyright © 2015 Clinics Cardive Publishing http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cardiovascular Topics
Furat, Cevdet
Dogan, Riza
Ilhan, Gokhan
Bayar, Ekrem
Ozpak, Berkan
Kara, Hakan
Bozok, Şahin
Telmisartan decreases microalbuminuria in patients with type 2 diabetes mellitus following coronary artery bypass grafting
title Telmisartan decreases microalbuminuria in patients with type 2 diabetes mellitus following coronary artery bypass grafting
title_full Telmisartan decreases microalbuminuria in patients with type 2 diabetes mellitus following coronary artery bypass grafting
title_fullStr Telmisartan decreases microalbuminuria in patients with type 2 diabetes mellitus following coronary artery bypass grafting
title_full_unstemmed Telmisartan decreases microalbuminuria in patients with type 2 diabetes mellitus following coronary artery bypass grafting
title_short Telmisartan decreases microalbuminuria in patients with type 2 diabetes mellitus following coronary artery bypass grafting
title_sort telmisartan decreases microalbuminuria in patients with type 2 diabetes mellitus following coronary artery bypass grafting
topic Cardiovascular Topics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558141/
https://www.ncbi.nlm.nih.gov/pubmed/27834982
http://dx.doi.org/10.5830/CVJA-2016-089
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