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Assessment of myocardial repolarisation parameters in patients with familial Mediterranean fever

BACKGROUND: Familial Mediterranean fever (FMF) is a chronic, recurrent auto-inflammatory disease characterised by self-terminating attacks of fever and sterile polyserositis. The main cause of death in auto-inflammatory diseasesis cardiovascular events. Additionally, auto-inflammatory diseases have...

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Autores principales: Karaman, Kayıhan, Karayakalı, Metin, Erken,, Ertuğrul, Demirtaş, Ahmet, Öztürk, Mustafa, Altunkaş, Fatih, Arısoy, Arif, Turan, Oğuzhan Ekrem, Ceyhan, Köksal, Çelik, Ataç
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Clinics Cardive Publishing 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558142/
https://www.ncbi.nlm.nih.gov/pubmed/28759086
http://dx.doi.org/10.5830/CVJA-2016-074
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author Karaman, Kayıhan
Karayakalı, Metin
Erken,, Ertuğrul
Demirtaş, Ahmet
Öztürk, Mustafa
Altunkaş, Fatih
Arısoy, Arif
Turan, Oğuzhan Ekrem
Ceyhan, Köksal
Çelik, Ataç
author_facet Karaman, Kayıhan
Karayakalı, Metin
Erken,, Ertuğrul
Demirtaş, Ahmet
Öztürk, Mustafa
Altunkaş, Fatih
Arısoy, Arif
Turan, Oğuzhan Ekrem
Ceyhan, Köksal
Çelik, Ataç
author_sort Karaman, Kayıhan
collection PubMed
description BACKGROUND: Familial Mediterranean fever (FMF) is a chronic, recurrent auto-inflammatory disease characterised by self-terminating attacks of fever and sterile polyserositis. The main cause of death in auto-inflammatory diseasesis cardiovascular events. Additionally, auto-inflammatory diseases have potential effects on the myocardial repolarisation parameters, including the T-wave peak-to-end (Tp-Te) interval, cTp-Te interval (corrected Tp-Te) and the cTp-Te/ QT ratio. The aim of this study was to analyse the efficacy of myocardial repolarisation alterations in anticipation of cardiovascular risks in patients with FMF. METHODS: This study included 66 patients with FMF and 58 healthy control subjects. Tp-Te and cTp-Te intervals and the cTp-Te/QT ratio were measured from the 12-lead electrocardiogram. RESULTS: In electrocardiographic parameters, analysis of QT, QT dispersion, corrected QT (QTc) and QTc dispersion were similar between the groups. The Tp-Te and cTp-Te intervals and Tp-Te/QT and cTp-Te/QT ratios were significantly prolonged in FMF patients. Multivariate linear regression analyses indicated that erythrocyte sedimentation rate was an independent predictor of a prolonged cTp-Te interval. CONCLUSIONS: Our study revealed that when compared with control subjects, Tp-Te and cTp-Te intervals and cTp-Te/QT ratio were increased in FMF patients.
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spelling pubmed-55581422017-08-30 Assessment of myocardial repolarisation parameters in patients with familial Mediterranean fever Karaman, Kayıhan Karayakalı, Metin Erken,, Ertuğrul Demirtaş, Ahmet Öztürk, Mustafa Altunkaş, Fatih Arısoy, Arif Turan, Oğuzhan Ekrem Ceyhan, Köksal Çelik, Ataç Cardiovasc J Afr Cardiovascular Topics BACKGROUND: Familial Mediterranean fever (FMF) is a chronic, recurrent auto-inflammatory disease characterised by self-terminating attacks of fever and sterile polyserositis. The main cause of death in auto-inflammatory diseasesis cardiovascular events. Additionally, auto-inflammatory diseases have potential effects on the myocardial repolarisation parameters, including the T-wave peak-to-end (Tp-Te) interval, cTp-Te interval (corrected Tp-Te) and the cTp-Te/ QT ratio. The aim of this study was to analyse the efficacy of myocardial repolarisation alterations in anticipation of cardiovascular risks in patients with FMF. METHODS: This study included 66 patients with FMF and 58 healthy control subjects. Tp-Te and cTp-Te intervals and the cTp-Te/QT ratio were measured from the 12-lead electrocardiogram. RESULTS: In electrocardiographic parameters, analysis of QT, QT dispersion, corrected QT (QTc) and QTc dispersion were similar between the groups. The Tp-Te and cTp-Te intervals and Tp-Te/QT and cTp-Te/QT ratios were significantly prolonged in FMF patients. Multivariate linear regression analyses indicated that erythrocyte sedimentation rate was an independent predictor of a prolonged cTp-Te interval. CONCLUSIONS: Our study revealed that when compared with control subjects, Tp-Te and cTp-Te intervals and cTp-Te/QT ratio were increased in FMF patients. Clinics Cardive Publishing 2017 /pmc/articles/PMC5558142/ /pubmed/28759086 http://dx.doi.org/10.5830/CVJA-2016-074 Text en Copyright © 2015 Clinics Cardive Publishing http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cardiovascular Topics
Karaman, Kayıhan
Karayakalı, Metin
Erken,, Ertuğrul
Demirtaş, Ahmet
Öztürk, Mustafa
Altunkaş, Fatih
Arısoy, Arif
Turan, Oğuzhan Ekrem
Ceyhan, Köksal
Çelik, Ataç
Assessment of myocardial repolarisation parameters in patients with familial Mediterranean fever
title Assessment of myocardial repolarisation parameters in patients with familial Mediterranean fever
title_full Assessment of myocardial repolarisation parameters in patients with familial Mediterranean fever
title_fullStr Assessment of myocardial repolarisation parameters in patients with familial Mediterranean fever
title_full_unstemmed Assessment of myocardial repolarisation parameters in patients with familial Mediterranean fever
title_short Assessment of myocardial repolarisation parameters in patients with familial Mediterranean fever
title_sort assessment of myocardial repolarisation parameters in patients with familial mediterranean fever
topic Cardiovascular Topics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558142/
https://www.ncbi.nlm.nih.gov/pubmed/28759086
http://dx.doi.org/10.5830/CVJA-2016-074
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